Results 51 to 60 of about 8,268,032 (366)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Evaluating groupware support for software engineering students [PDF]

, 2001
Software engineering tasks, during both development and maintenance, typically involve teamwork using computers. Team members rarely work on isolated computers.
Boldyreff, Cornelia, Drummond, Sarah, Ramage, Magnus   +2 more
core   +2 more sources

Systematic Mapping Studies in Software Engineering

International Conference on Evaluation & Assessment in Software Engineering, 2008
BACKGROUND: A software engineering systematic map is a defined method to build a classification scheme and structure a software engineering field of interest. The analysis of results focuses on frequencies of publications for categories within the scheme.
K. Petersen, R. Feldt, Shahid Mujtaba, Michael Mattsson   +3 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Standards of Validity and the Validity of Standards in Behavioral Software Engineering Research: The Perspective of Psychological Test Theory

, 2018
Background. There are some publications in software engineering research that aim at guiding researchers in assessing validity threats to their studies.
Gren, Lucas
core   +1 more source

Sustainability in Software Engineering [PDF]

, 2018
The intersection between software engineering re- search and the problems related to sustainability and green IT has been the subject of increasing attention.
berntsen, bourque, osborne, penzenstadler   +3 more
core   +2 more sources

Software requirement engineering over the federated environment in distributed software development process

Journal of King Saud University: Computer and Information Sciences
In the recent past, the distributed software development (DSD) process has become increasingly prevalent with the rapid evolution of the software development process.
Abdulaziz Alhumam, Shakeel Ahmed
doaj   +1 more source

Analysis of cryptographic mechanisms used in ransomware CryptXXX v3 [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2016
The main purpose of this paper was to analysis how malicious software is using cryptographic mechanisms. Reverse engineering were applied in order to discover mechanisms used in ransomware CryptXXX v3.
Michał Glet
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source