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Informatik Spektrum, 2020 Abstract“A Passion for Software-Engineering.” This was the headline of a 2015 newspaper article about Ernst Denert. And they were absolutely right. Ernst Denert is really passionate about developing software with excellent quality in a predictable and systematic style.
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Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Software engineering’s contribution to earthquake engineering
Earth Sciences Research Journal, 2013 Earthquakes are natural disasters which affect Mexico regularly. It is very important to obtain all information about them quickly, in order to speed up attention to population affected and if it is possible, applying prevention actions. At present time,
Abigail Zamora Hernandez +3 more
doaj
Towards data-driven software engineering skills assessment [PDF]
International Journal of Crowd Science, 2018 Purpose - Today’s software engineers often work in teams to develop complex software systems. Therefore, successful software engineering in practice require team members to possess not only sound programming skills such as analysis, design, coding and ...
Jun Lin +4 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Software Engineering for Research Software
, 2019 This poster describes work at the intersection of Software Engineering and Research ...
Carver, Jeffrey C., Milewicz, Reed
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FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
Tehnički Glasnik, 2019 The supply is not matching the demand on the market for software developers. While the enrolment in undergraduate computer science courses is increasing, few students are interested in and committed to becoming software developers.
Aziz Nanthaamornphong, Stephane Bressan
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