Results 101 to 110 of about 162,787 (208)

Talin1 Adhesion Morphology and Colocalization With Tensin3 Are Largely Unaffected by Polyacrylamide Substrate Stiffness

Cytoskeleton, EarlyView.
ABSTRACT Cells sense the stiffness of their extracellular matrix (ECM) and adapt their behavior accordingly. We investigated how ECM stiffness affects the spatial organization of talin1, a key mechanosensitive focal adhesion protein. Using polyacrylamide (PA) hydrogels with tunable stiffnesses (0.2–188 kPa), we analyzed cell morphology, migration ...
Joanna Hajduk, Patrycja Twardawa, Sylwia Bobis‐Wozowicz, Marta Szewczyk, Zenon Rajfur, Zbigniew Baster   +5 more
wiley   +1 more source

Bridging engineering and neuro-oncology: a scalable FastAPI-deployed CNN framework for real-time explainable brain tumor diagnosis. [PDF]

Front Neurosci
Nematzadeh S, Anka F, Ciftci F, Ayanoğlu KYU, Özarslan AC, Oncu E.   +5 more
europepmc   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Rural-urban differences in the economic contributions of veterinary practices across 10 states. [PDF]

Front Vet Sci
Neill CL, Baros J, ShalekBriski A.
europepmc   +1 more source

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, EarlyView.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

Epidemiological characteristics and trends of pre-hospital emergency care in Handan, China from 2011 to 2024. [PDF]

Front Public Health
Tian F, Lu S, Bi C, Wang X, Zhang X, Yang Z, Zhang L, Li J, Li P, Zhang H.   +9 more
europepmc   +1 more source

Character education as curriculum‐making in the humanities: A scoping review

The Curriculum Journal, EarlyView.
Abstract This scoping review examines how character education is conceptualised and enacted within humanities curricula across international contexts. While character education is widely promoted as supporting the development of ethical, civic and relational dispositions, its place within curriculum design remains contested, particularly in subjects ...
Jonathon Sargeant, Kylie Trask‐Kerr
wiley   +1 more source

Frailty, Comorbidities, and In-Hospital Outcomes in Older Cholangiocarcinoma Patients. [PDF]

J Clin Med
Sanchez MM, Sabillon CA, Paduano SJ, Egwim C, Ankoma-Sey V.   +4 more
europepmc   +1 more source

Pulmonary development in Squamata: Insights from embryonic studies using micro‐CT

Developmental Dynamics, EarlyView.
Abstract Background Pulmonary development in tetrapods is a complex process, especially within squamates, where single‐chambered, transitional, and multi‐chambered lungs can be found in adult animals. While the embryological development of the respiratory system of lizards and snakes was studied in a number of species between the 1830s and 1940s, the ...
Barbara G. Champini, Raul E. Diaz Jr., Emma R. Schachner, Wilfried Klein   +3 more
wiley   +1 more source

Advanced Analysis Tools for Two Wavelength Autofluorescence Imaging of Macular Xanthophyll Carotenoids: ALSTAR2 Baseline. [PDF]

Transl Vis Sci Technol
Berlin A, Goerdt L, Clark ME, Gao L, Swain TA, McGwin G, Owsley C, Sloan KR, Curcio CA.   +8 more
europepmc   +1 more source