Results 81 to 90 of about 15,654 (194)

Structural Constraints to Sustainable Supply Chain Diversification: Rare Earth Elements, Business Strategy and Resilience in the Energy Transition

Business Strategy and the Environment, EarlyView.
ABSTRACT Rare earth elements (REEs) are critical inputs for low‐carbon technologies, yet their supply chains remain highly concentrated and vulnerable. Although diversification is widely promoted as a strategy to enhance supply chain resilience, its feasibility in strategic material systems remains limited.
Klavdij Logožar
wiley   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Gibbs energy minimization thermodynamics for CO2 capture by aqueous amines: Conservation laws, concentration variables, and parameter consistency

The Canadian Journal of Chemical Engineering, EarlyView.
We clarify how Gibbs‐energy‐minimization models for aqueous‐amine CO2 capture fail when conservation constraints and concentration conventions are inconsistent. Exact standard‐state conversions and Reaktoro case studies show that P(CO2)‐loading fits can mask non‐unique parameters and wrong speciation, motivating complete water‐inclusive formulations ...
William R. Smith, William Rutherford, Allan M. M. Leal   +2 more
wiley   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Talin1 Adhesion Morphology and Colocalization With Tensin3 Are Largely Unaffected by Polyacrylamide Substrate Stiffness

Cytoskeleton, EarlyView.
ABSTRACT Cells sense the stiffness of their extracellular matrix (ECM) and adapt their behavior accordingly. We investigated how ECM stiffness affects the spatial organization of talin1, a key mechanosensitive focal adhesion protein. Using polyacrylamide (PA) hydrogels with tunable stiffnesses (0.2–188 kPa), we analyzed cell morphology, migration ...
Joanna Hajduk, Patrycja Twardawa, Sylwia Bobis‐Wozowicz, Marta Szewczyk, Zenon Rajfur, Zbigniew Baster   +5 more
wiley   +1 more source

The application of recent software technology to the access to patent information systems. EUR 11326 EN. Information Management [PDF]

, 1988
Vermeir, D., Laenens, J., Dierick, J.
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Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, EarlyView.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

Character education as curriculum‐making in the humanities: A scoping review

The Curriculum Journal, EarlyView.
Abstract This scoping review examines how character education is conceptualised and enacted within humanities curricula across international contexts. While character education is widely promoted as supporting the development of ethical, civic and relational dispositions, its place within curriculum design remains contested, particularly in subjects ...
Jonathon Sargeant, Kylie Trask‐Kerr
wiley   +1 more source

Blurring the Boundaries: An Investigation of Eating Disorder Recovery Content on TikTok

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorder recovery content is widely circulated on TikTok. We thematically analyzed recovery content on TikTok, examined its associations with symptom severity among individuals with eating disorders, and assessed its co‐occurrence with pro‐eating disorder material within their TikTok feeds.
Scott Griffiths, Isabel Martyn, Harish Kannan, Ben Stone, Emma Austen, Edoardo Tescari, Usha Nattala, Wesley Grey, Noa Brittain, Deborah Mitchison, Jake Linardon, Jasmine Fardouly, Emily Harris   +12 more
wiley   +1 more source