Results 31 to 40 of about 1,625,789 (274)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

An Approach for Evolving Transformation Sequences Using Hybrid Genetic Algorithms

International Journal of Computational Intelligence Systems, 2020
The digital transformation revolution has been crawling toward almost all aspects of our lives. One form of the digital transformation revolution appears in the transformation of our routine everyday tasks into computer executable programs in the form of
Ahmed Maghawry, Mohamed Kholief, Yasser Omar, Rania Hodhod   +3 more
doaj   +1 more source

A Method for Considering Error Propagation in Reliability Estimation of Component-Based Software Systems [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2019
Component-based software engineering has proved itself as a strong pillar in software engineering community. Large number of factors are involved in the success of software product developed using Component-based software engineering, for instance ...
Preeti Malik, Lata Nautiyal, Mangey Ram
doaj   +1 more source

Training, Quality Assurance Factors, and Tools Investigation: a Work Report and Suggestions on Software Quality Assurance [PDF]

, 1991
Previously, several research tasks have been conducted, some observations were obtained, and several possible suggestions have been contemplated involving software quality assurance engineering at NASA Johnson. These research tasks are briefly described.
Lee, Pen-Nan
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Evaluating User Experience E-Commerce Platform Using Hassenzahl Framework

International Journal of Applied Sciences and Smart Technologies
The Hassenzahl framework of UX provides an approach in measuring user experience of a product which covers such the following aspects : be goals, do goals, and motor goals.
Stevanus Wisnu Wijaya, Sesaria Wisnu Wijaya   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Attacks and countermeasures on federated learning via historical knowledge modeling

Journal of King Saud University: Computer and Information Sciences
Federated learning has emerged as a promising paradigm for privacy-preserving multi-source data fusion. However, its distributed nature makes it vulnerable to poisoning attacks.
Songsong Zhang, Zhengliang Jiang, Hang Gao, Suying Gui, Tiegang Gao   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An Assessment of Educational Benefits from the OpenOrbiter Space Program

Education Sciences, 2013
This paper analyzes the educational impact of the OpenOrbiter Small Spacecraft Development Initiative, a CubeSat development program underway at the University of North Dakota.
David Whalen, Jeremy Straub
doaj   +1 more source