Results 61 to 70 of about 6,322,248 (257)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Optimized Differential Evolution Algorithm for Software Testing

International Journal of Computational Intelligence Systems, 2018
Differential evolution (DE) algorithms for software testing usually exhibited limited performance and stability owing to possible premature-convergence-related aging during evolution processes.
Xiaodong Gou, Tingting Huang, Shunkun Yang, Mengxuan Su, Fuping Zeng   +4 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Is Code Co-Committal an Indicator of Evolutionary Coupling in Software Repositories?

Software
Software repositories such as Git are significant sources of metadata about software projects, containing information such as modified files, change authors, and often commentary describing the change.
Niall Price, David Cutting, Vahid Garousi   +2 more
doaj   +1 more source

EOS software evolution enabling LHC Run 3 [PDF]

EPJ Web of Conferences
EOS has been the main storage system at CERN for more than a decade, continuously improving in order to meet the ever evolving requirements of the LHC experiments and the whole physics user community.
Caffy Cedric, Amadio Guilherme, Guenther Jaroslav, Lekshmanan Abhishek, Mascetti Luca, Peters Andreas, Reis Manuel, Simon Michal Kamil, Sindrilaru Elvin, Smith David   +9 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Evolution of communities of software: using tensor decompositions to compare software ecosystems

Applied Network Science, 2019
Modern software development is often a collaborative effort involving many authors through the re-use and sharing of code through software libraries.
Oliver A. Blanthorn, Colin M. Caine, Eva M. Navarro-López   +2 more
doaj   +1 more source

Design for future: managed software evolution

Computer Science - Research and Development, 2014
Innovative software engineering methodologies, concepts and tools which focus on supporting the ongoing evolution of complex software, in particular regarding its continuous adaptation to changing functional and quality requirements as well as platforms ...
U. Goltz, Ralf H. Reussner, M. Goedicke, W. Hasselbring, Lukas Märtin, B. Vogel‐Heuser   +5 more
semanticscholar   +1 more source