Results 71 to 80 of about 6,322,298 (304)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

LSTM Attention-Driven Similarity Learning for Effective Bug Localization

Applied Sciences
Objective: The complexity of software systems, with their multifaceted functionalities and intricate source code structures, poses significant challenges for developers in identifying and resolving bugs.
Geunseok Yang, Jinfeng Ji, Eontae Kim
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

EvoFreq: visualization of the Evolutionary Frequencies of sequence and model data

BMC Bioinformatics, 2019
Background High throughput sequence data has provided in depth means of molecular characterization of populations. When recorded at numerous time steps, such data can reveal the evolutionary dynamics of the population under study by tracking the changes ...
Chandler D. Gatenbee, Ryan O. Schenck, Rafael R. Bravo, Alexander R. A. Anderson   +3 more
doaj   +1 more source

TASSEL: software for association mapping of complex traits in diverse samples

Bioinform., 2007
Association analyses that exploit the natural diversity of a genome to map at very high resolutions are becoming increasingly important. In most studies, however, researchers must contend with the confounding effects of both population and family ...
Peter J. Bradbury, Zhiwu Zhang, Dallas E. Kroon, T. Casstevens, Yogesh Ramdoss, E. Buckler   +5 more
semanticscholar   +1 more source

Software Language Evolution

2008 15th Working Conference on Reverse Engineering, 2008
By abstraction and factoring out domain specific knowledge, model driven engineering addresses the problem of increasing software complexity. Both models and meta models are generally subject to evolution, yet evolution of a meta model can cause conforming models to no longer conform and thereby no longer be usable.
openaire   +3 more sources

Understanding and simulating software evolution [PDF]

2013 35th International Conference on Software Engineering (ICSE), 2013
The important roles of software in modern life have prompted people to study software evolution.This dissertation takes a scientific perspective to model the dynamics of software evolution, and verify the model by simulation.Empirical studies of software evolution have discovered many emergent phenomena, such as the power law distributions in different
openaire   +2 more sources