Results 51 to 60 of about 9,947 (259)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Rough Noise-Filtered Easy Ensemble for Software Fault Prediction
IEEE Access, 2018 Software fault prediction is the very important research topic for software quality assurance. Data-driven approaches provide robust mechanisms to deal with software fault prediction. However, the prediction performance of the model highly depends on the
Saman Riaz, Ali Arshad, Licheng Jiao
doaj +1 more source
Optimal Release Time Estimation of Software System using Box-Cox Transformation and Neural Network [PDF]
International Journal of Mathematical, Engineering and Management Sciences, 2018 The determination of the software release time for a new software product is the most critical issue for designing and controlling software development processes.
Momotaz Begum, Tadashi Dohi
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
What Ruined Your Cake: Impacts of Code Modifications on Bug Distribution
IEEE Access, 2020 In the current decade, software systems have been more intensively employed in every aspect of our lives. However, it is disappointing that the quality of software is far from satisfactory.
Jun Ai, Haoran Guo, W. Eric Wong
doaj +1 more source
Salp swarm optimizer for modeling the software fault prediction problem
Journal of King Saud University: Computer and Information Sciences, 2022 This paper proposes the salp swarm algorithm (SSA) combined with a backpropagation neural network (BPNN) to solve the software fault prediction (SFP) problem.
Sofian Kassaymeh +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Prediction of Fault Fix Time Transition in Large-Scale Open Source Project Data
Data, 2019 Open source software (OSS) programs are adopted as embedded systems regarding their server usage, due to their quick delivery, cost reduction, and standardization of systems.
Hironobu Sone +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source