Results 61 to 70 of about 11,335 (296)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Rough Noise-Filtered Easy Ensemble for Software Fault Prediction

IEEE Access, 2018
Software fault prediction is the very important research topic for software quality assurance. Data-driven approaches provide robust mechanisms to deal with software fault prediction. However, the prediction performance of the model highly depends on the
Saman Riaz, Ali Arshad, Licheng Jiao
doaj   +1 more source

Optimal Release Time Estimation of Software System using Box-Cox Transformation and Neural Network [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2018
The determination of the software release time for a new software product is the most critical issue for designing and controlling software development processes.
Momotaz Begum, Tadashi Dohi
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Feature Selection Using Golden Jackal Optimization for Software Fault Prediction

Mathematics, 2023
A program’s bug, fault, or mistake that results in unintended results is known as a software defect or fault. Software flaws are programming errors due to mistakes in the requirements, architecture, or source code. Finding and fixing bugs as soon as they
Himansu Das, Sanjay Prajapati, Mahendra Kumar Gourisaria, Radha Mohan Pattanayak, Abdalla Alameen, Manjur Kolhar   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Salp swarm optimizer for modeling the software fault prediction problem

Journal of King Saud University: Computer and Information Sciences, 2022
This paper proposes the salp swarm algorithm (SSA) combined with a backpropagation neural network (BPNN) to solve the software fault prediction (SFP) problem.
Sofian Kassaymeh, Salwani Abdullah, Ph.D, Mohammed Azmi Al-Betar, Mohammed Alweshah   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Investigating Automatic Static Analysis Results to Identify Quality Problems: an Inductive Study [PDF]

, 2012
Background: Automatic static analysis (ASA) tools examine source code to discover "issues", i.e. code patterns that are symptoms of bad programming practices and that can lead to defective behavior.
Nico Zazworka, Forrest Shull, Vetro', Antonio, Zazworka, N., Shull, F., Seaman C., Shaw, M., Zazworka N., Carolyn Seaman, Seaman, C., Michele A. Shaw, Shull F., Shaw M., Antonio Vetro   +13 more
core   +1 more source

Prediction of Fault Fix Time Transition in Large-Scale Open Source Project Data

Data, 2019
Open source software (OSS) programs are adopted as embedded systems regarding their server usage, due to their quick delivery, cost reduction, and standardization of systems.
Hironobu Sone, Yoshinobu Tamura, Shigeru Yamada   +2 more
doaj   +1 more source