Results 61 to 70 of about 4,766,212 (242)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Feature Selection Using Golden Jackal Optimization for Software Fault Prediction

Mathematics, 2023
A program’s bug, fault, or mistake that results in unintended results is known as a software defect or fault. Software flaws are programming errors due to mistakes in the requirements, architecture, or source code. Finding and fixing bugs as soon as they
Himansu Das, Sanjay Prajapati, Mahendra Kumar Gourisaria, Radha Mohan Pattanayak, Abdalla Alameen, Manjur Kolhar   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

What Ruined Your Cake: Impacts of Code Modifications on Bug Distribution

IEEE Access, 2020
In the current decade, software systems have been more intensively employed in every aspect of our lives. However, it is disappointing that the quality of software is far from satisfactory.
Jun Ai, Haoran Guo, W. Eric Wong
doaj   +1 more source

Salp swarm optimizer for modeling the software fault prediction problem

Journal of King Saud University: Computer and Information Sciences, 2022
This paper proposes the salp swarm algorithm (SSA) combined with a backpropagation neural network (BPNN) to solve the software fault prediction (SFP) problem.
Sofian Kassaymeh, Salwani Abdullah, Ph.D, Mohammed Azmi Al-Betar, Mohammed Alweshah   +3 more
doaj   +1 more source

Reliability prediction in model driven development [PDF]

, 2005
Evaluating the implications of an architecture design early in the software development lifecycle is important in order to reduce costs of development.
David S. Rosenblum, Genaı́na N. Rodrigues, Genaína N. Rodrigues, Rosenblum, D.S., Uchitel, S., Rodrigues, G.N., Sebastian Uchitel   +6 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Prediction of Fault Fix Time Transition in Large-Scale Open Source Project Data

Data, 2019
Open source software (OSS) programs are adopted as embedded systems regarding their server usage, due to their quick delivery, cost reduction, and standardization of systems.
Hironobu Sone, Yoshinobu Tamura, Shigeru Yamada   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source