Results 61 to 70 of about 397,696 (287)

Data supporting the high-accuracy haplotype imputation using unphased genotype data as the references

Data in Brief, 2016
The data presented in this article is related to the research article entitled “High-accuracy haplotype imputation using unphased genotype data as the references” which reports the unphased genotype data can be used as reference for haplotyping ...
Wenzhi Li, Wei Xu, Shaohua He, Li Ma, Qing Song   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

GRAPES: a software for parallel searching on biological graphs targeting multi-core architectures. [PDF]

PLoS ONE, 2013
Biological applications, from genomics to ecology, deal with graphs that represents the structure of interactions. Analyzing such data requires searching for subgraphs in collections of graphs. This task is computationally expensive.
Rosalba Giugno, Vincenzo Bonnici, Nicola Bombieri, Alfredo Pulvirenti, Alfredo Ferro, Dennis Shasha   +5 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Improving Interoperability in Scientific Computing via MaRDI Open Interfaces

Journal of Open Research Software
MaRDI Open Interfaces is a software project aimed at improving reuse and interoperability in scientific computing by alleviating the difficulties of crossing boundaries between different programming languages, such as C, Julia, or Python, in which ...
Dmitry I. Kabanov, Stephan Rave, Mario Ohlberger   +2 more
doaj   +1 more source

BioCRNpyler: Compiling chemical reaction networks from biomolecular parts in diverse contexts.

PLoS Computational Biology, 2022
Biochemical interactions in systems and synthetic biology are often modeled with chemical reaction networks (CRNs). CRNs provide a principled modeling environment capable of expressing a huge range of biochemical processes.
William Poole, Ayush Pandey, Andrey Shur, Zoltan A Tuza, Richard M Murray   +4 more
doaj   +1 more source

Software Implementation

Abstract The “cooking recipes” in this book shall provide guidance and encouragement for custom ADRC implementations. To demonstrate that the transition from principles to practice is immediately possible based on the results from previous chapters, we will implement discrete-time variants in software form in this chapter; both using a model ...
Gernot Herbst, Rafal Madonski
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Software Engineering Implementation Research [PDF]

Advances in Computer Science Research, 2016
Software engineering implementation is to apply software engineering theory for software development organizations in order to improve the product development time (T), quality (Q), cost (C), service (S) of software development organization. The most important is the engineering software development process, namely the establishment of a process with ...
openaire   +1 more source