Results 81 to 90 of about 397,696 (287)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 Parallel algorithm searching the maximum of the objective function using CUDA technology based on the modified method of dynamic programming is presented.
E. N. Seredin
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Facilitating harmonized data quality assessments. A data quality framework for observational health research data collections with software implementations in R. [PDF]
BMC Med Res Methodol, 2021 Schmidt CO +9 more
europepmc +1 more source
Multiple-Implementation Testing of Supervised Learning Software [PDF]
, 2016 Machine learning (ML) software, used to implement an ML algorithm, is widely used in many application domains such as financial, business, and engineering domains. Faults in ML software can cause substantial losses in these application domains.
Alebiosu, Oreoluwa +3 more
core
An Analysis Framework for Hardware and Software Implementations with Applications from Cryptography
, 2018 With the richness of present-day hardware architectures, tightening the synergy between hardware and software has attracted a great attention. The interest in unified approaches paved the way for newborn frameworks that target hardware and software co ...
Damaj, Issam, Kasbah, Safaa
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Безопасность информационных технологий, 2014 The article is a brief survey of hardware vulnerability analysis methods that might be applicable against cryptographic algorithm implementations. Those methods are based on physical properties of a device processing the algorithm.
Roman Gevorkovich Korkikian +2 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source