Results 41 to 50 of about 84,866 (259)

The effectiveness of refactoring, based on a compatibility testing taxonomy and a dependency graph [PDF]

open access: yes, 2006
In this paper, we describe and then appraise a testing taxonomy proposed by van Deursen and Moonen (VD&M) based on the post-refactoring repeatability of tests.
Counsell, S   +4 more
core   +1 more source

Architecture, design and source code comparison of ns-2 and ns-3 network simulators [PDF]

open access: yes, 2010
Ns-2 and its successor ns-3 are discrete-event simulators. Ns- 3 is still under development, but offers some interesting characteristics for developers while ns-2 still has a big user base.
Amaya Rodríguez, Claudio Antonio   +4 more
core   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Static Analyser for Java-Based Object-Oriented Software Metrics [PDF]

open access: yes, 1999
Software metrics play a major role In the software development. Not only software metrics help in understanding the size and complexity of software systems, but they are also helpful in improving the quality of software systems.
Abu Al-Ese, Hasan Mugbil Khalaf
core  

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont   +4 more
wiley   +1 more source

An empirical study of evolution of inheritance in Java OSS [PDF]

open access: yes, 2006
Previous studies of Object-Oriented (OO) software have reported avoidance of the inheritance mechanism and cast doubt on the wisdom of ‘deep’ inheritance levels.
Counsell, S, Nasseri, E, Shepperd, M J
core  

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó   +17 more
wiley   +1 more source

DeltaImpactFinder: Assessing Semantic Merge Conflicts with Dependency Analysis [PDF]

open access: yes, 2015
In software development, version control systems (VCS) provide branching and merging support tools. Such tools are popular among developers to concurrently change a code-base in separate lines and reconcile their changes automatically afterwards. However,
Dias Martin   +4 more
core   +5 more sources

Central Dysmyelination in SSADH‐Deficient Humans and Mice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer   +11 more
wiley   +1 more source

Quantitative Iron Measurements in the Basal Ganglia of NBIA Patients Using QSM: Insights From a Tertiary Center

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurodegeneration with brain iron accumulation (NBIA) comprises rare genetic disorders characterized by predominantly extrapyramidal symptoms and iron deposition in the basal ganglia. Conventional magnetic resonance imaging (MRI) detects qualitative changes but cannot accurately quantify iron accumulation. Quantitative susceptibility
Özge Uygun   +19 more
wiley   +1 more source

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