Results 141 to 150 of about 7,465 (300)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A software maintainability attributes model

, 1996
Examines the factors that affect the maintainability of a software. The proposed model can be used to highlight the need to improve the quality of the product so that proper and efficient maintenance is feasible without much difficulty.
master administrator
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PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Enhancing Software Maintainability through LLM-Assisted Code Refactoring

High code quality, particularly in terms of maintainability, is crucial for ensuring that software remains efficient and adaptable over time, while minimizing long-term maintenance costs.
Riccardo Coppola, Flavio Giobergia, Amirali Changizi, Meelad Dashti, Kimia Dorrani, Tommaso Fulcini, Filippo Ricca, Domenico Amalfitano, Damiano Distante   +8 more
core   +1 more source

A Case Study of Software Product Line for Business Applications Changeability Prediction

Journal of Information and Organizational Sciences, 2014
The changeability, a sub-characteristic of maintainability, refers to the level of effort which is required to do modifications to a software product line (SPL) application component. Assuming dependencies between SPL application components and reference
Zdravko Roško, Vjeran Strahonja
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Scripting Language for Embedded Software Automatic Test

Kongzhi Yu Xinxi Jishu, 2019
In order to improve the convenience of human-computer interaction and the maintainability of test cases in black-box automated testing, a script language based on natural language was proposed in this paper.
LONG Xiaoqi, ZHANG Jiahuan, TANG Lin, CHEN Zehua, JIANG Peng   +4 more
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Extraction of objects from legacy systems: an example using cobol legacy systems [PDF]

, 1998
In the last few years the interest in legacy information system has increased because of the escalating resources spent on their maintenance. On the other hand, the importance of extracting knowledge from business rules is becoming a crucial issue for ...
Salurso, Maria Anna
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