Results 121 to 130 of about 7,465 (300)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

An Empirical investigation into metrics for object-oriented software

Object-Oriented methods have increased in popularity over the last decade, and are now the norm for software development in many application areas. Many claims were made for the superiority of object-oriented methods over more traditional methods, and ...
Cartwright, Michelle Helen
core  

SOFTWARE MAINTAINABILITY MEASUREMENT: A TASK COMPLEXITY PERSPECTIVE

, 2010
Software maintainability is one of the most crucial quality attributes of a software product. Software engineering researchers and practitioners have devoted considerable effort to developing “good design” methods, rules and principles to improve ...
He, Lulu
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Software Documentation Guidelines For Maintainability

, 2014
Software maintenance is the final stage in the software engineering process; and can also be the longest and most costly. The ability of, and ease in which software upkeep and change is performed is an important software quality attribute called ...
Huber, Justin Roger
core  

The impact of maintainability on component-based software systems

, 2003
There is a great deal of inconsistency and vagueness in the treatment of and terminology involved with software maintainability. This is exacerbated by the fact that there are a number of different dimensions of maintainability, each requiring specific ...
Matinlassi, Mari, Niemelä, Eila
core   +1 more source

Survivability Prediction of Open Source Software with Polynomial Regression

Applied Sciences
In modern software development, OSS (Open Source Software) has become a crucial element. However, if OSS have few contributors and are lacking in maintenance activities, such as bug fixes, are used, it can lead to significant costs and resource ...
Sohee Park, Ryeonggu Kwon, Gihwon Kwon
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Software Requirements Risk and Maintainability

, 2005
In order to continue to make progress in software measurement, as it pertains to reliability and maintainability, there must be a shift in emphasis from design and code metrics to metrics that characterize the risk of making requirements changes.
Norman F. Schneidewind
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source