Results 101 to 110 of about 7,465 (300)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysing the Analysers: An Investigation of Source Code Analysis Tools

Applied Computer Systems
The primary expectation from a software system revolves around its functionality. However, as the software development process advances, equal emphasis is placed on the quality of the software system for non-functional attributes like maintainability and
Bhutani Vikram, Toosi Farshad Ghassemi, Buckley Jim   +2 more
doaj   +1 more source

Supervised Machine Learning for Technical Debt in Python: Analysis and Prediction

Machine Learning and Knowledge Extraction
The appearance of technical debt (TD) becomes a critical problem, posing challenges related to software maintainability and its quality within the context of fast modern software development.
Elif Fırıncı, Mohanad Alayedi
doaj   +1 more source

Urgensi Maintainability Software e-SPT dan Faktor-faktor yang Berpengaruh terhadap Alokasi Penerimaan Pajak Penghasilan (PPh) Pasal 25 Badan di KPP Madya Malang – Jawa Timur

Jurnal Ilmiah Bisnis dan Ekonomi Asia, 2017
Penelitian ini bertujuan untuk mengetahui urgensi maintainability software e-SPT dan faktor-faktor yang berpengaruh terhadap alokasi penerimaan Pajak Penghasilan (PPh) Pasal 25 Badan, dasar pemilihan Pajak Penghasilan (PPh) Pasal 25 Badan karena total ...
Agus Rahman Alamsyah
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Assessing optimal software architecture maintainability

, 2001
Over the last decade, several authors have studied the maintainability of software architecture. In particular, the assessment of maintainability has received attention.
Po Bengtsson, Jan Bosch
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Clustering for Monitoring Software Systems Maintainability Evolution

, 2009
This paper presents ongoing work on using data mining clustering to support the evaluation of software systems' maintainability. As input for our analysis we employ software measurement data extracted from Java source code.
Antonellis, P., Tsirakis, N., Theodoridis, E., Antoniou, D., Tjortjis, C., Kanellopoulos, Y., Makris, C.   +6 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Software maintainability prediction

, 2020
The pre-processing techniques were applied in the bug prediction datasets published in http://bug.inf.usi.ch/download.php by D'Ambros et al to produce a new version of these datasets that are suitable for software maintainability prediction.
Hadeel Alsolai
core   +1 more source