Results 131 to 140 of about 4,695,708 (306)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Evaluating software maintenance effort: The COME Matrix
, 2011 If effort estimates are not easily assessed upfront by software maintainers we may have serious problems with large maintenance projects, or when we make repeated maintenance changes to software. This is particularly problematic when inaccurate estimates
June Verner +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Information Needs of Developers for Program Comprehension during Software Maintenance Tasks
, 2008 Software engineers undertaking maintenance tasks often work on unfamiliar code, requiring developers to search for, relate, and collect information relevant to the maintenance task. The goal of this research is to create theories that describe the nature
Layman, Lucas Michael
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Introducing workflow management in software maintenance processes
, 2001 Software organizations are moving from traditional software factory models towards virtual organization models, where distributed teams converge in a temporary network with the aim of integrating different competences or solving problems in a cooperative
Betti S +3 more
core
Empirical evaluation of software maintenance technologies
, 1996 Technology evaluation is part of the decision-making process of any software organization. Unlike conventional wisdom, empirical evaluation strives to avoid biased conclusions by relying on observation and looking for pitfalls in the evaluation process ...
LANUBILE, Filippo
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Modeling Software VulnerabilitiesWith Vulnerability Cause Graphs
, 2006 When vulnerabilities are discovered in software, which often happens after deployment, they must be addressed as part of ongoing software maintenance.
Claudiu Duma +7 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source