Results 41 to 50 of about 1,408,133 (243)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Liquid Level Measurement Model Outside of Closed Containers Based on Continuous Sound Wave Amplitude

Sensors, 2018
This research put forward an exogenous liquid level measurement method based on continuous sound wave amplitude. The distribution of round piston transducers in the sound field of a metal solid was analyzed by building 15 Multi-Gaussian Beam ...
Yanjun Zhang, Bin Zhang, Liang Zhang, Yunchao Li, Xiaolong Gao, Zhaojun Liu   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Temperature Drift Compensation for Four-Mass Vibration MEMS Gyroscope Based on EMD and Hybrid Filtering Fusion Method

Micromachines, 2023
This paper presents an improved empirical modal decomposition (EMD) method to eliminate the influence of the external environment, accurately compensate for the temperature drift of MEMS gyroscopes, and improve their accuracy.
Zhong Li, Yuchen Cui, Yikuan Gu, Guodong Wang, Jian Yang, Kai Chen, Huiliang Cao   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Large-scale time-lapse microscopy of Oct4 expression in human embryonic stem cell colonies

Stem Cell Research, 2016
Identification and quantification of the characteristics of stem cell preparations is critical for understanding stem cell biology and for the development and manufacturing of stem cell based therapies.
Kiran Bhadriraju, Michael Halter, Julien Amelot, Peter Bajcsy, Joe Chalfoun, Antoine Vandecreme, Barbara S. Mallon, Kye-yoon Park, Subhash Sista, John T. Elliott, Anne L. Plant   +10 more
doaj   +1 more source

Measuring Software Technology [PDF]

, 1984
Results are reported from a series of investigations into the effectiveness of various methods and tools used in a software production environment. The basis for the analysis is a project data base, built through extensive data collection and process instrumentation. The project profiles become an organizational memory, serving as a reference point for
W. W. Agresti, D. N. Card, V. E. Church, G. Page, F. E. McGarry   +4 more
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Stochasticity Prevails but Differs: Tissue‐Specific Assembly of Gut Microbiomes Across Seasons in an Amphibian Model

Ecology and Evolution
Gut microbiota generally undergoes dynamic remodeling in concert with multifaceted self‐regulation of amphibian hosts during key life stages, such as metamorphosis and hibernation.
Xiaowei Song, Yuanyuan Zhai, Mengyang Zhang, Jingyuan Guo, Benjun Guo, Chaolong Zhang, Jin Jin, Weiye Wang, Yuanping Xu, Bicheng Zhu, Xiangzhen Li   +10 more
doaj   +1 more source