Results 61 to 70 of about 1,536,107 (311)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Refractive Index Sensor Based on the Fano Resonance in Metal–Insulator–Metal Waveguides Coupled with a Whistle-Shaped Cavity

Micromachines, 2022
A plasmonic refractive index sensor based on surface plasmon polaritons (SPPs) that consist of metal–insulator–metal (MIM) waveguides and a whistle-shaped cavity is proposed.
Bo Li, Huarong Sun, Huinan Zhang, Yuetang Li, Junbin Zang, Xiyuan Cao, Xupeng Zhu, Xiaolong Zhao, Zhidong Zhang   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Stochasticity Prevails but Differs: Tissue‐Specific Assembly of Gut Microbiomes Across Seasons in an Amphibian Model

Ecology and Evolution
Gut microbiota generally undergoes dynamic remodeling in concert with multifaceted self‐regulation of amphibian hosts during key life stages, such as metamorphosis and hibernation.
Xiaowei Song, Yuanyuan Zhai, Mengyang Zhang, Jingyuan Guo, Benjun Guo, Chaolong Zhang, Jin Jin, Weiye Wang, Yuanping Xu, Bicheng Zhu, Xiangzhen Li   +10 more
doaj   +1 more source

A Feedback-Based Linear Spectral Fitting Demodulation Method for Interrogating Extrinsic Fabry–Pérot Interferometric Sensors

Photonics
Spectral demodulation is a crucial component of the extrinsic Fabry–Pérot interferometric (EFPI) sensing technology. In this study, a feedback-based linear spectral fitting demodulation method is proposed for interrogating EFPI sensors.
Qianyu Ren, Yunteng Dai, Jiamin Chen, Junchan Li, Zhiyuan Li, Conghui Duan, Kangchi Liu   +6 more
doaj   +1 more source

Large-scale time-lapse microscopy of Oct4 expression in human embryonic stem cell colonies

Stem Cell Research, 2016
Identification and quantification of the characteristics of stem cell preparations is critical for understanding stem cell biology and for the development and manufacturing of stem cell based therapies.
Kiran Bhadriraju, Michael Halter, Julien Amelot, Peter Bajcsy, Joe Chalfoun, Antoine Vandecreme, Barbara S. Mallon, Kye-yoon Park, Subhash Sista, John T. Elliott, Anne L. Plant   +10 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source