Results 161 to 170 of about 346,980 (259)

Scalable Agile Framework for Execution in AI for Medical AI Ethics Policy Design in Small- and Medium-Sized Enterprises.

J Med Internet Res
Nemteanu I, Mancebo A, Joe L, Lopez R, Lopez P, Pettine WW.   +5 more
europepmc   +1 more source

Dosimetric Discrepancy Between Whole-Lung and Lobe-Specific Metrics in Lung Stereotactic Body Radiotherapy and Its Implications for Regional Dose Assessment. [PDF]

Cureus
Miura H, Ozawa S, Kenjo M.
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

"Mellitus Metrics"-Systematic Review of Glucometric Reporting within Hospital-Based Diabetes Studies (2006-2023). [PDF]

J Diabetes Sci Technol
Yoo JWS, Wang R, Kyi M, Fourlanos S, Barmanray RD.   +4 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Inner Retinal Reflectivity Loss and Concurrent Thickening Predict Short-Term Conversion to Neovascular AMD. [PDF]

Invest Ophthalmol Vis Sci
Trinh M, Borrelli E, Reibaldi M, Foti C, Nivison-Smith L.   +4 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Automated MR-only radiotherapy outperforms CT-based radiotherapy and decreases hands-on time for head-and-neck cancer treatment. [PDF]

Clin Transl Radiat Oncol
Lauwers I, Capala M, Kaushik S, Ruskó L, Cozzini C, Szabó E, Kékesi Á, Deák-Karancsi B, Wyatt J, Pearson R, Verduijn G, Wiesinger F, Hernandez-Tamames J, Petit S.   +13 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Enhanced preoperative prediction for microvascular invasion in hepatocellular carcinoma through an optimized MR Radiomics combination strategy and machine learning predictor. [PDF]

Front Med (Lausanne)
Feng M, Yang Y, Dai Z, Chen Z, Li L, Wu Z, Li X, Guo T, Meng Y, Li Q, Zhao Z, Li T, Zhang J, Kang Y.   +13 more
europepmc   +1 more source