Results 101 to 110 of about 543,049 (269)

Numerical Study of Vortex-Induced Vibration Characteristics of a Long Flexible Marine Riser

Journal of Marine Science and Engineering
In ocean engineering, interactions between ocean currents and risers lead to regular vortex shedding on both sides of the riser, causing structural deformation.
Jiahe Zou, Bo Zhou, Wenxin Yi, Conghong Lu, Hui Liu, Wenqing Luo   +5 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Topology optimization for fluid–structure interaction problems considering heat transfer performance

Theoretical and Applied Mechanics Letters
Effectively controlling the deformation and temperature of heated structures is crucial for achieving high-performance active cooling through fluid flow.
Yuhui Jing, Li An, Sinan Yi, Jing Li, Pai Liu, Yaguang Wang, Xiaopeng Zhang   +6 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Automated Controlled Experimentation on Software by Evolutionary Bandit Optimization

, 2017
Controlled experiments, also called A/B tests or split tests, are used in software engineering to improve products by evaluating variants with user data.
Ros, Rasmus,, Runeson, Per,, Lund University., Bjarnason, Elizabeth,   +3 more
core   +1 more source

Flow Field and Motion Characteristics of Trans-Medium Submersible during Take-off and Landing on Water Surface

水下无人系统学报
In order to explore the evolution of the flow field structure and motion characteristics of the trans-medium submersible during the take-off and landing on water surface, the volume of fluid(VOF) multiphase flow model, the shear stress transfer(SST) k-ω ...
Deshun LU, Shaoqian ZHANG, Haoyu WANG, Tiezhi SUN   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A DISTRIBUTED APPROACH TO ANT COLONY OPTIMIZATION [PDF]

Swarm Intelligence(SI) is the emergent collective intelligence of groups of simple agents. Economy is an example of SI. Simulating an economy using Ant Colony algorithms would allow prediction and control of fluctuations in the complex emergent behavior ...
Eng. Sorin Ilie Ph. D Student, Prof. Costin Bădică Ph. D   +1 more
core  

The interface reaction and microstructure control in friction stir lap welding of Al and Ti dissimilar alloys

Journal of Materials Research and Technology
The objective of this study is to investigate the mechanism by which the mechanical properties of Al and Ti dissimilar alloys are controlled during friction stir lap welding (FSLW).
Z. Zhang, X.Y. Zhang, Y.L. Liu, H.N. Xing   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source