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Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez+3 more
wiley +1 more source
Teaching software process modeling [PDF]
Most university curricula consider software processes to be on the fringes of software engineering (SE). Students are told there exists a plethora of software processes ranging from RUP over V-shaped processes to agile methods. Furthermore, the usual students' programming tasks are of a size that either one student or a small group of students can ...
Marco Kuhrmann+2 more
openaire +4 more sources
What Should a Good Software Requirements Specification Include? Results of a Survey
Software requirements specification is an important foundation of the software development process. It documents the requirements, expectations, and restrictions for a system to be developed.
Rączkowska-Gzowska Karolina+1 more
doaj +1 more source
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek+15 more
wiley +1 more source
Process Mining Framework for Software Processes
Software development processes are often not explicitly modelled and sometimes even chaotic. In order to keep track of the involved documents and files, engineers use software configuration management systems. Along the way, those systems collect and store information on the software development process itself.
Vladimir Rubin+5 more
openaire +4 more sources
Software-Engineering Process Simulation (SEPS) model [PDF]
The Software Engineering Process Simulation (SEPS) model is described which was developed at JPL. SEPS is a dynamic simulation model of the software project development process.
Abdel-Hamid, T.+2 more
core +1 more source
Automating the Object-Oriented Software Development Process: Workshop Report [PDF]
Cost-effective realization of robust, adaptable and reusable software systems demands efficient and effective management of the overall software production process.
Aksit, Mehmet, Tekinerdogan, Bedir
core +3 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner+7 more
wiley +1 more source
Comparison of Gaussian process modeling software [PDF]
Gaussian process fitting, or kriging, is often used to create a model from a set of data. Many available software packages do this, but we show that very different results can be obtained from different packages even when using the same data and model ...
Ankenman, Bruce E.+2 more
core +2 more sources
Using grounded theory to understand software process improvement: A study of Irish software product companies [PDF]
Software Process Improvement (SPI) aims to understand the software process as it is used within an organisation and thus drive the implementation of changes to that process to achieve specific goals such as increasing development speed, achieving higher ...
Blaxter+22 more
core +1 more source