Results 61 to 70 of about 21,534,990 (291)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

open access: yesFEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász   +6 more
wiley   +1 more source

Robust Reconstruction of the Void Fraction from Noisy Magnetic Flux Density Using Invertible Neural Networks

open access: yesSensors
Electrolysis stands as a pivotal method for environmentally sustainable hydrogen production. However, the formation of gas bubbles during the electrolysis process poses significant challenges by impeding the electrochemical reactions, diminishing cell ...
Nishant Kumar   +5 more
doaj   +1 more source

Patterns of Software Development Process [PDF]

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2011
"Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">This article presents a set of patterns that can be found to perform best practices in software processes that
Sandro Javier Bolaños Castro   +2 more
doaj  

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

Software Development Process Changes in the Telecommunications Industry [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2006
The tremendous changes in the telecommunications business in the last several years drove changes in the software development processes of telecommunications equipment providers.
John Kevin Doyle   +2 more
doaj  

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

A Survey on Software Fault Localization

open access: yesIEEE Transactions on Software Engineering, 2016
Software fault localization, the act of identifying the locations of faults in a program, is widely recognized to be one of the most tedious, time consuming, and expensive - yet equally critical - activities in program debugging.
W. E. Wong   +4 more
semanticscholar   +1 more source

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