Results 41 to 50 of about 597,862 (247)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Software Testing in Small IT Companies: A (not only) South African Problem

South African Computer Journal, 2011
Small software companies make for the majority of software companies around the world, but their software development processes are often not as clearly defined and structured as in their larger counterparts. Especially the test process is often the most
Stefan Gruner, Johan van Zyl
doaj  

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

FEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick II, Thomas Löhr, Peifeng Xu, Nicholas C. T. Gallagher, Bernardino Ghetti, Byron Caughey, Sjors H. W. Scheres, Michele Vendruscolo   +9 more
wiley   +1 more source

Mapeo sistemático sobre la evaluación de la agilidad en organizaciones de desarrollo de software

Iteckne, 2019
Los enfoques ágiles de desarrollo de software proporcionan grandes beneficios para las organizaciones, sin embargo su implementación está sujeta a muchos desafíos. Para las organizaciones es importante conocer el nivel de agilidad alcanzado y las brechas
Wilson Alfredo Ortega-Ordóñez, César Jesús Pardo-Calvache, Francisco José Pino-Correa   +2 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Diagnóstico al iniciar la mejora de proceso de software / Diagnosis when starting the software process improvement

Revista Científica de Ingeniería Industrial, 2014
En el presente artículo se fundamenta la utilidad de realizar un diagnóstico al iniciar la mejora de procesos de software, haciendo uso de los factores críticos de éxito para identificar las fortalezas y las debilidades de acometer el cambio.
Yaimí Trujillo-Casañola, Ailyn Febles-Estrada, Giraldo León-Rodríguez, Yadainy Betancourt- Rodriguez, Odannis Enamorado-PérezI, Yixi Sanchez-Osorio   +5 more
doaj  

SPIIMM: Toward a Model for Software Process Improvement Implementation and Management in Global Software Development

IEEE Access, 2017
Software development organizations are globalizing their activities by adopting the phenomenon of global software development (GSD), mainly due to the significant return on investment it offers. Various challenges are associated with the software process
Arif Ali Khan, Jacky W. Keung, Fazal-E-Amin, M. Abdullah-Al-Wadud   +3 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Software quality management and software process improvement in Denmark [PDF]

Proceedings of the 34th Annual Hawaii International Conference on System Sciences, 2005
The software business is a fast growing industry sector and lack of quality has a significant consequence for society and economy. However, reports about unfinished development projects, project overrruns and system and software failures are still the rule. Software quality management (SQM) standards and software process improvement (SPI) methodologies
Karlheinz Kautz, F. Ramzan
openaire   +3 more sources