Results 41 to 50 of about 652,827 (236)
IEEE Access, 2017 Software development organizations are globalizing their activities by adopting the phenomenon of global software development (GSD), mainly due to the significant return on investment it offers. Various challenges are associated with the software process
Arif Ali Khan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Mapeo sistemático sobre la evaluación de la agilidad en organizaciones de desarrollo de software
Iteckne, 2019 Los enfoques ágiles de desarrollo de software proporcionan grandes beneficios para las organizaciones, sin embargo su implementación está sujeta a muchos desafíos. Para las organizaciones es importante conocer el nivel de agilidad alcanzado y las brechas
Wilson Alfredo Ortega-Ordóñez +2 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Success Factors for Conducting Software-Process Improvement in Web-Based Software Projects
Cybernetics and Information TechnologiesContinuous Software Process Improvement (SPI) is essential for achieving and maintaining high-quality software products. Web-based software enterprises, comprising a substantial proportion of global businesses and forming a cornerstone of the world’s ...
Al-Rousan Thamer
doaj +1 more source
New Advances in the Machining of Hard Metals using Physics-Based Modeling
Engineering Transactions, 2014 The machining of hard metals historically has been understood to be challenging and costly due to its material properties (such as titanium’s low thermal conductivity and high hardness, and nickel’s rapid work-hardening and high strength at elevated ...
Troy D. MARUSICH +4 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source