Results 51 to 60 of about 1,937,401 (263)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A New Optimized Hybrid Model Based On COCOMO to Increase the Accuracy of Software Cost Estimation [PDF]
Journal of Advances in Computer Engineering and Technology, 2018 The literature review shows software development projects often neither meet time deadlines, nor run within the allocated budgets. One common reason can be the inaccurate cost estimation process, although several approaches have been proposed in this ...
Ramin Saljoughinejad, Vahid Khatibi
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
International Journal of Information Systems and Project Management, 2023 Software project teams (SPTs) are critical stakeholders. Their contribution in successful delivery of software projects is unquestionable. However, the empirical evidence of their importance seems to exist on paper only, as software project managers ...
Robert Hans, Ernest Mnkandla
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Software Engineering Team Project - lessons learned [PDF]
e-Informatica Software Engineering Journal, 2013 In the 2010/11 academic year the Institute of Informatics at Wroclaw University of Technology issued ’Software Engineering Team Project’ as a course being a part of the final exam to earn bachelor’s degree.
Bogumiła Hnatkowska
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
<p dir="ltr">This document outlines the deliverables for the Requirements, Analysis and Design workflows of the Unified Process for the UFS COVID-19 Screening System. The UFS COVID-19 Screening System serves to automate the process of screening campus staff, student and visitors for COVID-19 symptoms before accessing the campus.</p>
Phuthi, R. G. +2 more
openaire +2 more sources
Core Factors for Software Projects Success
JOIV: International Journal on Informatics Visualization, 2019 The successful software project can be defined as the project that meets the planned quality, cost, schedule, and effort. It has been suggested that there are many reasons which might lead to software project success. Several success and failure factors
Mohammad Ibraigheeth +1 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source