Results 91 to 100 of about 428,429 (314)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

value-based multiple software projects scheduling with genetic algorithm

, 2009
Chinese Acad Sci, ISCAS Lab Internet Software TechnologiesScheduling human resources to multiple projects under various resource requirements, constraints and value objectives is a key problem that many software organizations struggle with.
Yang Qiusong, Xiao Junchao, Wang Qing, Liu Dapeng, Li Mingshu, Xie Lizi   +5 more
core  

Collaboration patterns in distributed software development projects

, 2012
The need for educating future software engineers in the field of global software engineering is recognized by many educational institutions. In this paper we outline the characteristics of an existing global software development course run over a period ...
Cavrak, Igor,, Crnkovic, Ivica,, Ivica Crnkovic, Orlic, Marin,, Igor Cavrak, Marin Orlic   +5 more
core   +1 more source

Generative adversarial networks-based software development effort estimation for small datasets

Scientific African
In project management, accurately estimating the effort required for software projects is crucial. With the right configuration, artificial neural networks (ANNs) can be used to build predictive models since they learn from previous data and minimize ...
Fatima Ezzahra Boujida, Fatima Azzahra Amazal, Ali Idri   +2 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

“It Takes All Kinds”: A Simulation Modeling Perspective on Motivation and Coordination in Libre Software Development Projects [PDF]

This paper presents a stochastic simulation model to study implications of the mechanisms by which individual software developers’ efforts are allocated within large and complex open source software projects. It illuminates the role of different forms of
Jean-Michel Dalle, Paul A. David
core  

STRUCTURAL MODEL OF THE INFORMATIVE SYSTEM OF DECISION MAKING AS TO RESOURCES MANAGEMENT IN THE PORTFOLIO OF PROJECTS OF THE AGRICULTURAL ENTERPRISE

Вісник Національного технічного університету «ХПÌ». Серія: Стратегічне управління, управління портфелями, програмами та проектами, 2016
The peculiarities of management by projects at the agricultural production are analyzed. The available information software systems of the automated management by projects have a number of shortcomings, that does impossible its use in an agricultural ...
Василь Олегович ТИМОЧКО, Роман Іванович ПАДЮКА, Іван Миколайович ГОРОДЕЦЬКИЙ   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

EFFICIENT TEAM BUILDING FOR ON-TIME PROJECTS [PDF]

When we think to software development projects we consider that a strong set of requirements is defined and team members always follow initial planning. Well, this was a specific orientation in traditional software developments methods and methodologies.
Dan Benţa, Ştefan Ioan Niţchi, Remus Felix Pop, Darius Șuta   +3 more
core  

Gitana: A software project inspector

Science of Computer Programming, 2018
Abstract The development of software projects entails significant implementation and collaboration activities, typically supported by tools such as issue trackers, code review tools and Version Control Systems. However, these tools only provide a partial view of the project and often lack of advanced querying mechanisms, thus hampering the analysis ...
Valerio Cosentino, Javier Luis Cánovas Izquierdo, Jordi Cabot   +2 more
openaire   +1 more source