Results 131 to 140 of about 428,429 (314)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Using Free/Libre Open Source Software Projects as E-learning Tools

, 2010
Free/Libre Open Source Software (FLOSS) projects can be considered as learning environments in which heterogeneous communities get together to exchange knowledge through discussion and put it into practice through actual contributions to software ...
Sowe, Sulayman K, Cerone, Antonio
core   +1 more source

Combinatorial Testing in Software Projects

, 2012
Software systems continuously grow in size and code complexity, the latter most evident through greater component interconnectedness. This leaves more space for bugs which introduce risks such as exposure to security threats. Combinatorial testing looks for interaction failures in order to improve the system security and effectiveness guarantees.
Brčić, Mario, Kalpić, Damir
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Community-Based Production of Open Source Software: What Do We Know About the Developers Who Participate? [PDF]

This paper seeks to close an empirical gap regarding the motivations, personal attributes and behavioral patterns among free/libre and open source (FLOSS) developers, especially those involved in community-based production, and its findings on the ...
Joseph Shapiro, Paul David
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Implementing and improving the SEI risk management method in a university software project [PDF]

Although risk management approaches appeared more than one decade ago, there is the evidence of low penetration rate of their techniques in software projects.
JOSE MANUEL ESTEVES
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The impact of open source software on the strategic choices of firms developing proprietary software [PDF]

, 2006
Open source software (OSS) is now posing significant competition to proprietary or closed source software (CSS) in several software markets. In this paper, we characterize the response of a firm developing CSS to the presence of an OSS in its market.
Jaisingh, J, See-To, E W K, Tam, K Y
core  

Enhanced weather classification using xception with SENet and attention mechanisms

Frontiers in Environmental Science
IntroductionWeather classification plays a crucial role in applications such as environmental monitoring, disaster management, and smart city infrastructure.
Gunjan Shandilya, Sheifali Gupta, Abdul Khader Jilani Saudagar, Sunnia Ikram, Ateeq Ur Rehman, Isabel De la Torre Díez, Heba G. Mohamed, Ramón Pali Casanova, Ramón Pali Casanova, Ramón Pali Casanova, Ángel Kuc Castilla, Ángel Kuc Castilla, Ángel Kuc Castilla, Ángel Kuc Castilla, Upinder Kaur   +14 more
doaj   +1 more source