Results 111 to 120 of about 1,980,136 (283)
Sequential Innovation, Patents, and Imitation [PDF]
We argue that when discoveries are "sequential" (so that each successive invention builds in an essential way on its predecessors) patent protection is not as useful for encouraging innovation as in a static setting.
Eric Maskin, James Bessen
core
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Model Averaging Software for Dichotomous Dose Response Risk Estimation [PDF]
Model averaging has been shown to be a useful method for incorporating model uncertainty in quantitative risk estimation. In certain circumstances this technique is computationally complex, requiring sophisticated software to carry out the computation ...
A. John Bailer, Matthew W. Wheeler
core +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Effective Factors on Occupational Noise Protection Among Industrial Workers [PDF]
Hearing protection is very important for workers in noisy work environments, although the willingness of workers to wear hearing protectors depends heavily on some factors. This study evaluated effective factors on use of hearing protection devices.
تبرائی, یاسر +2 more
core
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
HARDWARE-SOFTWARE COMPLEX OF TRANSMISSION PIPELINE ANTICORROSION PROTECTION
Advanced Engineering Research, 2010 A structural construction scheme for the hardware-software control complex of transmission pipeline electrochemical anticorrosion protection equipment is offered.
Alexey O. KRIVTSOV +1 more
doaj
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Network Localization of Fatigue in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo +12 more
wiley +1 more source
HARDWARE-SOFTWARE COMPLEX OF TRANSMISSION PIPELINE ANTICORROSION PROTECTION
Вестник Донского государственного технического университета, 2018 A structural construction scheme for the hardware-software control complex of transmission pipeline electrochemical anticorrosion protection equipment is offered.
Alexey O. KRIVTSOV +1 more
doaj