Results 41 to 50 of about 746,394 (306)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Compiler protection techniques against software vulnerabilities exploitation
Труды Института системного программирования РАН, 2018 Software vulnerabilities are critical for security. All C/C++ programs contain significant amount of vulnerabilities. Some of them can be successfully exploitable by attacker to gain control of the execution flow.
A. R. Nurmukhametov +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Jurnal IUS, 2016 The higher the age and quality enhancement technology, the higher the level of knowledge of technology, with a number of associations hackers and expert coding for trying to duplicate a video game that has been produced by the creators in the form of ...
Robby Akhmad Surya Dilaga
doaj +1 more source
Routing Protection Algorithm Based on Hybrid Software Defined Network [PDF]
Jisuanji gongcheng, 2020 In order to enable the Software Defined Network(SDN) to cope with the possible situations of single link failure in network,this paper proposes a routing protection algorithm based on hybrid SDN.The routing protection algorithm coping with the single ...
GENG Haijun, ZHANG Wei, YIN Xia
doaj +1 more source
Subject-matter patentability and effective protection of computer programs [PDF]
, 2002 Computer programs can now be protected by patents in the EPO, the US, and Japan. Patents can also be obtained for software implemented business methods in the US.
Koo, Dae-Hwan
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Data criticality estimation in software applications [PDF]
, 2003 In safety-critical applications it is often possible to exploit software techniques to increase system's fault- tolerance. Common approaches are based on data redundancy to prevent data corruption during the software execution.
Di Natale, Giorgio +9 more
core +1 more source