Results 61 to 70 of about 746,394 (306)

A Model-Based Framework for Simplified Collaboration of Legal and Software Experts in Data Protection Assessments

, 2022
The protection of personal data has become an increasingly important issue. Legal norms focused on data protection, such as the GDPR, provide legally binding requirements for systems that process personal data.
Sterz,Leonie, Gerking,Christopher, Boltz,Nicolas, Raabe,Oliver   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

ESP32-Based Hardware Key for Software Application Protection

Applied Sciences
In the current context, classic software licensing and protection mechanisms based exclusively on host application checks can be circumvented by patching, emulation and replay attacks in user-controlled environments.
Alexandru-Ion Popovici, Florin-Daniel Anton   +1 more
doaj   +1 more source

Open-source QSAR models for pKa prediction using multiple machine learning approaches

Journal of Cheminformatics, 2019
Background The logarithmic acid dissociation constant pKa reflects the ionization of a chemical, which affects lipophilicity, solubility, protein binding, and ability to pass through the plasma membrane.
Kamel Mansouri, Neal F. Cariello, Alexandru Korotcov, Valery Tkachenko, Chris M. Grulke, Catherine S. Sprankle, David Allen, Warren M. Casey, Nicole C. Kleinstreuer, Antony J. Williams   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Analysis of Software Protectors

Безопасность информационных технологий, 2011
This article presents an overview of software products designed to protect software against unauthorized copying or protectors. The author analyses advantages and disadvantages of popular protectors and also covers new tendencies, technologies and ...
V. A. Bukasov
doaj  

Grounding transient response of lightning protection GTIERRAS software

Revista Facultad de Ingeniería Universidad de Antioquia, 2006
A computer program developed in Matlab (GTIERRAS) from an electromagneticbased model is used to assess grounding impedances and the behavior of grounding electrodes of arbitrary shapes under lightning impulses. Impedance, currents and voltages, or other
Héctor David Gómez Montoya, Esteban Velilla Hernández, Germán Moreno Ospina, Jaime Alejandro Valencia Velásquez   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Code Renewability for Native Software Protection [PDF]

Software protection aims at safeguarding assets embedded in software by preventing and delaying reverse engineering and tampering attacks. This paper presents an architecture and supporting tool flow to renew parts of native applications dynamically ...
Coppens, B., Cabutto, Alessandro, Falcarin, Paolo, Wyseur, B., Abrath, B., Van Den Broeck, J., De Sutter, B.   +6 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source