Results 71 to 80 of about 1,996,535 (294)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Severity-sensitive norm-governed multi-agent planning [PDF]
, 2017 This research was funded by Selex ES. The software developed during this research, including the norm analysis and planning algorithms, the simulator and harbour protection scenario used during evaluation is freely available from doi:10.5258/SOTON ...
Gasparini, Luca +2 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Towards a synthesis of multimedia and intelligent tutoring systems : a dissertation presented in partial fulfilment of the requirements for the degree of Master of Science in Computer Science at Massey University [PDF]
, 1998 Multimedia is being used in almost every field. This study is about the use of multimedia in the area of intelligent tutoring systems. This project studies the advantages and disadvantages of interactive multimedia and intelligent tutoring systems, and ...
Vethanayagam, Emma A. K
core
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
MULTIFACTOR AUTHENTICATION FOR SOFTWARE PROTECTION
Diyala Journal of Engineering Sciences, 2015 Software protection is a mechanism to make software systems more difficult (or impossible) to be accessed by attackers. Such mechanisms are gaining more importance nowadays for increasing number of attacks on the software systems in the large internet ...
Ali J. Abboud
doaj
Digital Rights Management, Intellectual Property Rights Protection and Economic development: The case of digital piracy in the South Mediterranean countries [PDF]
: The potential benefits that could be gained from information technologies in South Mediterranean economies are constrained by both DRM and institutional protection related to Intellectual Property Rights.
Alaoui Belghiti, Moulay Abdelaziz +2 more
core +1 more source
Interactive Password Schemes [PDF]
, 2004 Only the abstract is available for this technical report.Usual password schemes suffer from the flaw that they are easy to steal. An attacker who has correctly observed a login session (by peeping, wiretapping and/or by launching a "man-in-the-middle ...
Itkis, Gene, Maiss, Arwa
core +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source