Results 141 to 150 of about 4,615,317 (347)

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

open access: yesMolecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric   +11 more
wiley   +1 more source

Applying Software Craftsmanship Practices to a Scrum Project: an Experience Report [PDF]

open access: yesarXiv, 2016
The Software Craftsmanship manifesto has defined values and principles that software development teams should follow to deliver quality software that fulfills functional and non-functional requirements without dealing with high amounts of technical debt. Software craftsmanship approach to software development prioritizes technical practices in order to
arxiv  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

Prediction of rate of improvement of software quality and development effort on the basis of Degreeof excellence with respect to number of lines of code [PDF]

open access: yesarXiv, 2014
The objective of this research work is to improve the degree of excellence by removing the number of exceptions from the software. The modern age is more concerned with the quality of software. Extensive research is being carried out in this direction. The rate of improvement of quality of software largely depends on the development time.
arxiv  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

How Does API Migration Impact Software Quality and Comprehension? An Empirical Study [PDF]

open access: yesarXiv, 2019
The migration process between different third-party software libraries is hard, complex and error-prone. Typically, during a library migration process, developers opt to replace methods from the retired library with other methods from a new library without altering the software behavior.
arxiv  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Test software quality issues and connections to international standards

open access: yesActa Universitatis Sapientiae: Informatica, 2013
This paper examines how ISO/IEC 9126-1 and ISO/IEC 25010 quality models can be applied to software testing products in industrial environment. We present a set of code smells for test systems written in TTCN-3 and their categorization according to ...
Kovács Attila, Szabados Kristóf
doaj   +1 more source

Significance of Coupling and Cohesion on Design Quality [PDF]

open access: yesarXiv, 2014
In recent years, the complexity of the software is increasing due to automation of every segment of application. Software is nowhere remained as one-time development product since its architectural dimension is increasing with addition of new requirements over a short duration.
arxiv  

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