Results 151 to 160 of about 4,615,317 (347)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Estudio de similitud del proceso de gestión de riesgos en proyectos de outsourcing de software: utilización de un método Similarity study of risk management process in software outsourcing projects: using a method

open access: yesRevista Ingenierías Universidad de Medellín, 2010
En este artículo, se realiza un estudio de estándares y modelos de ingeniería de software con el fin de determinar similitudes entre los mismos, desde el punto de vista del proceso de gestión de riesgos en el ámbito de outsourcing de software.
Gloria Piedad Gasca Hurtado
doaj  

Monitoring service quality: methods and solutions to implement a managerial dash-board to improve software development [PDF]

open access: yesarXiv, 2014
The software used for running and handling the inter-bank network framework provides services with extremely strict uptime (above 99.98 percent) and quality requirements, thus tools to trace and manage changes as well as metrics to measure process quality are essential.
arxiv  

Pragmatic quality metrics for evolutionary software development models [PDF]

open access: yes
Due to the large number of product, project, and people parameters which impact large custom software development efforts, measurement of software product quality is a complex undertaking.
Royce, Walker
core   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

open access: yesMolecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan   +6 more
wiley   +1 more source

FABASOFT BEST PRACTICES AND TEST METRICS MODEL

open access: yesJournal of Information and Organizational Sciences, 2007
Software companies have to face serious problems about how to measure the progress of test activities and quality of software products in order to estimate test completion criteria, and if the shipment milestone will be reached on time.
Nadica Hrgarek
doaj  

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