Results 41 to 50 of about 1,958,016 (266)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

De novo virulence feature discovery and risk assessment in Klebsiella pneumoniae based on microbial genome vectorization

Communications Biology
Bacterial pathogenicity has traditionally focused on gene-level content with experimentally confirmed functional properties. Hence, significant inferences are made based on similarity to known pathotypes and DNA-based genomic subtyping for risk.
Kristen L. Beck, Akshay Agarwal, Alison Laufer Halpin, L. Clifford McDonald, Susannah L. McKay, Alyssa G. Kent, James H. Kaufman, Vandana Mukherjee, Christopher A. Elkins, Edward Seabolt   +9 more
doaj   +1 more source

A DIGITAL QUALITY ASSESSMENT OF BAMBOOSHOOTS.AI FOR HARVEST AND PEST DETECTION [PDF]

Proceedings on Engineering Sciences
This research offered an in-depth evaluation of "BambooShoots.AI," a platform aiding bamboo cultivators in harvest timing and pest detection. Using a quantitative method, it incorporated Lund A.M.'s USE Questionnaire (2001) and usage data analysis to ...
Charlot L. Maramag , Thelma D. Palaoag
doaj   +1 more source

Predicting Software Cohesion Metrics with Machine Learning Techniques

Applied Sciences, 2023
The cohesion value is one of the important factors used to evaluate software maintainability. However, measuring the cohesion value is a relatively difficult issue when tracing the source code manually. Although there are many static code analysis tools,
Elif Nur Haner Kırğıl, Tülin Erçelebi Ayyıldız   +1 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Understanding the Impact of Emotions on the Quality of Software Artifacts

IEEE Access, 2021
This paper proposes a framework for investigating the impact of emotions on the quality of software artifacts and portrays some observations captured during the development of several software engineering projects.
Khaled M. Khan, Moutaz Saleh
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A Novel Lightweight Solo Software Development Methodology With Optimum Security Practices

IEEE Access, 2020
The diffusion of software into all areas of life and all forms of business, increases the demand for high-quality and secure software products. Software development methodologies are designed to improve the quality of software by incorporating practices ...
Sibonile Moyo, Ernest Mnkandla
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Software Change Prediction: A Systematic Review and Future Guidelines [PDF]

e-Informatica Software Engineering Journal, 2019
Background: The importance of Software Change Prediction (SCP) has been emphasized by several studies. Numerous prediction models in literature claim to effectively predict change-prone classes in software products. These models help software managers in
Ruchika Malhotra, Megha Khanna
doaj   +1 more source