Results 51 to 60 of about 1,993,684 (265)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Software Change Prediction: A Systematic Review and Future Guidelines [PDF]
e-Informatica Software Engineering Journal, 2019 Background: The importance of Software Change Prediction (SCP) has been emphasized by several studies. Numerous prediction models in literature claim to effectively predict change-prone classes in software products. These models help software managers in
Ruchika Malhotra, Megha Khanna
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A Machine Learning Based Monitoring Framework for Side-Channel Information Leaks
IEEE Open Journal of the Computer Society, 2021 Computer and network security is an ever important field of study as information processed by these systems is of ever increasing value. The state of research on direct attacks, such as exploiting memory safety or shell input errors is well established ...
Michael Lescisin, Qusay H. Mahmoud
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Scientific Reports$$PM_{2.5}$$ , a major air pollutant, often carries toxic components such as polycyclic aromatic hydrocarbons (PAHs), which pose potential health risks.
Zeming Huang +5 more
doaj +1 more source
INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY, 2012 In the given paper I present the information regarding quality metrics. Different quality factors can be imposing with relation to cost, schedule and rework. It’s very important to make quality assurance plans. For that you have to cover many milestones which can be represented in time sheets.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Considerations for regulation and evaluation of digital mental health technologies
Digital HealthDigital mental health technologies (DMHTs) are becoming well established within mental health services and through direct-to-consumer models. Due to their scalable nature, DMHTs may support services to bridge the gap between demand and the available ...
Gareth Hopkin +6 more
doaj +1 more source