Results 81 to 90 of about 11,449,331 (358)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Fatal Software Failures in Spaceflight

Encyclopedia
Space exploration has become an integral part of modern society, and since its early days in the 1960s, software has grown in importance, becoming indispensable for spaceflight.
Christian R. Prause, Ralf Gerlich, Rainer Gerlich   +2 more
doaj   +1 more source

Towards a Catalogue of Software Quality Metrics for Infrastructure Code [PDF]

Journal of Systems and Software, 2020
Stefano Dalla Palma, Dario Di Nucci, Fabio Palomba, D. Tamburri   +3 more
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Tools for monitoring software quality in information systems development and maintenance: five key challenges and a design proposal

International Journal of Information Systems and Project Management
As software grows in size and complexity, organizations increasingly apply tools to automatically assess software quality of information systems during development and maintenance.
Rolf-Helge Pfeiffer, Jon Aaen
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Dependencies among Architectural Views Got from Software Requirements Based on a Formal Model

Applied Computer Systems, 2014
A system architect has software requirements and some unspecified knowledge about a problem domain (e.g., an enterprise) as source information for assessment and evaluation of possible solutions and getting the target point, a preliminary software design.
Osis Janis, Asnina Erika, Donins Uldis, García-Díaz Vicente   +3 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

SOFTWARE TESTING ESTIMATION: BIBLIOGRAPHIC SURVEY IN BRAZILIAN AND INTERNATIONAL ENVIRONMENTS

Brazilian Journal of Operations & Production Management, 2017
The methodologies used in the market regarding pricing practices related to software testing activity are strongly based on empiricism, without the parameters and criteria that are widely accepted, what does not confer the due credibility in terms of ...
Fernando Oliveira de Araujo, Luciana Vago Matieli   +1 more
doaj   +1 more source