Results 81 to 90 of about 1,993,684 (265)
Assessing the impact of software quality models in healthcare software systems. [PDF]
Health Syst (Basingstoke), 2023 Ronchieri E, Canaparo M.
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Improving bioinformatics software quality through incorporation of software engineering practices. [PDF]
PeerJ Comput Sci, 2022 Noor A.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Vojnotehnički Glasnik, 2017 The paper emphasizes the importance of software usability as a key quality characteristic of software during its use. At the beginning of the paper, a retrospective of formal definitions of usability is given in order to show the evolution of views on
Nebojša D. Đorđević
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Impact of time pressure on software quality: A laboratory experiment on a game-theoretical model. [PDF]
PLoS One, 2021 Basten D +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Software Code Smell Prediction Model Using Shannon, Rényi and Tsallis Entropies
Entropy, 2018 The current era demands high quality software in a limited time period to achieve new goals and heights. To meet user requirements, the source codes undergo frequent modifications which can generate the bad smells in software that deteriorate the quality
Aakanshi Gupta +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source