Results 41 to 50 of about 731,215 (313)
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Software reliability deals with the probability that software will not cause the failure of a system in a specified time interval. Software reliability growth models (SRGMs) are used to predict future behaviour from known characteristics of software ...
Jabeen, G., +5 more
core +1 more source
Explainability features are intended to provide insight into the internal mechanisms of an Artificial Intelligence (AI) device, but there is a lack of evaluation techniques for assessing the quality of provided explanations.
Miguel A. Lago +3 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Design of Ellipsoid and Spherical Combined Light Source for Uniform Flux and Color Mixing
In this letter, an ellipsoid–spherical combined light source structure is presented for the purpose of uniform flux and color mixing, when considering heat dissipation.
Rui-Min Zeng +8 more
doaj +1 more source
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Reliability in the whole life cycle of building systems [PDF]
Purpose – The purpose of this research is to show that reliability analysis and its implementation will lead to an improved whole life performance of the building systems, and hence their life cycle costs (LCC). Design/methodology/approach – This paper
Sidhu, J. +13 more
core +1 more source
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Bayesian inference for a software reliability model using metrics information. [PDF]
In this paper, we are concerned with predicting the number of faults N and the time to next failure of a piece of software. Information in the form of software metrics data is used to estimate the prior distribution of N via a Poisson regression model ...
Rodríguez Bernal, María Teresa +3 more
core
Reliability and validity in comparative studies of software prediction models
Empirical studies on software prediction models do not converge with respect to the question "which prediction model is best?" The reason for this lack of convergence is poorly understood.
I. Myrtveit +5 more
core +1 more source

