Results 41 to 50 of about 731,215 (313)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

An improved software reliability prediction model by using high precision error iterative analysis method

, 2019
Software reliability deals with the probability that software will not cause the failure of a system in a specified time interval. Software reliability growth models (SRGMs) are used to predict future behaviour from known characteristics of software ...
Jabeen, G.,, Gul Jabeen, Afzal, Wasif,, Ping Luo, Wasif Afzal, Luo, P.,   +5 more
core   +1 more source

Evaluating Explainability: A Framework for Systematic Assessment of Explainable AI Features in Medical Imaging

Bioengineering
Explainability features are intended to provide insight into the internal mechanisms of an Artificial Intelligence (AI) device, but there is a lack of evaluation techniques for assessing the quality of provided explanations.
Miguel A. Lago, Ghada Zamzmi, Brandon Eich, Jana G. Delfino   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Design of Ellipsoid and Spherical Combined Light Source for Uniform Flux and Color Mixing

IEEE Photonics Journal, 2019
In this letter, an ellipsoid–spherical combined light source structure is presented for the purpose of uniform flux and color mixing, when considering heat dissipation.
Rui-Min Zeng, Ze-Tian Tang, Cheng-Xi Xia, Yang Wang, Shan Jin, Xin Ren, Li-Feng Bian, Zhao Ding, Chen Yang   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reliability in the whole life cycle of building systems [PDF]

, 2006
Purpose – The purpose of this research is to show that reliability analysis and its implementation will lead to an improved whole life performance of the building systems, and hence their life cycle costs (LCC). Design/methodology/approach – This paper
Sidhu, J., Neale, K., Wu, Shaomin, Neale, Keith, Clements-Croome, Derek, Albany, B., Desmond, Duncan, Wu, S., Albany, Bob, Sidhu, Jogi, Fairey, Vic, Clements-Croome, Derek J., Desmond, D., Fairey, V.   +13 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Bayesian inference for a software reliability model using metrics information. [PDF]

, 2001
In this paper, we are concerned with predicting the number of faults N and the time to next failure of a piece of software. Information in the form of software metrics data is used to estimate the prior distribution of N via a Poisson regression model ...
Rodríguez Bernal, María Teresa, Wiper, Michael Peter, Wiper, Michael P., Rodríguez Bernal, M. T.   +3 more
core  

Reliability and validity in comparative studies of software prediction models

, 2005
Empirical studies on software prediction models do not converge with respect to the question "which prediction model is best?" The reason for this lack of convergence is poorly understood.
I. Myrtveit, E. Stensrud, Myrtveit, I, Shepperd, MJ, Stensrud, E, M. Shepperd   +5 more
core   +1 more source