Results 31 to 40 of about 467,057 (287)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Formalism and Language Tools for Semantics Specification of Software Libraries

Моделирование и анализ информационных систем, 2016
The paper is dedicated to the specification of the structure and the behaviour of soft-ware libraries. It describes the existing problems of libraries specifications.
V. M. Itsykson
doaj   +1 more source

Detecting Functional Requirements Inconsistencies within Multi-teams Projects Framed into a Model-based Web Methodology [PDF]

, 2016
One of the most essential processes within the software project life cycle is the REP (Requirements Engineering Process) because it allows specifying the software product requirements.
Escalona Cuaresma, María José, García García, Julián Alberto, González Enríquez, José, Urbieta, Matias   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Modeling the external software interface for requirements specification [PDF]

, 1989
Requirements specification is an important part of the software, indeed the system, development process. It is critical that this effort be started early.
Melhart, Bonnie E.
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An Intelligent Model to Predict Functional and Non-Functional Requirements From Software Requirements Specification

IEEE Access
Automated classification of Functional Requirements (FRs) and Non-Functional Requirements (NFRs) is a fundamental task in requirements engineering, yet it remains challenging due to the short length, domain specificity, and severe class imbalance of ...
Martina Girgis Said, Laila M. El-Fangary, Safaa M. Azzam, Amr A. Abohany   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Formalizing the use case model: A model-based approach.

PLoS ONE, 2020
In general, requirements expressed in natural language are the first step in the software development process and are documented in the form of use cases. These requirements can be specified formally using some precise mathematical notation (e.g.
Qamar Uz Zaman, Aamer Nadeem, Muddassar Azam Sindhu   +2 more
doaj   +1 more source

Requirements management system browser software requirements specification [PDF]

, 1996
The purpose of this document is to define the essential user requirements for the Requirements Management System Browser (RMSB) application. This includes specifications for the Graphical User Interface (GUI) and the supporting database structures. The RMSB application is needed to provide an easy to use PC-based interface to browse system engineering ...
openaire   +2 more sources