Results 51 to 60 of about 467,057 (287)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Knowledge Base for an Intelligent System in order to Identify Security Requirements for Government Agencies Software Projects

MATEC Web of Conferences, 2016
It has been evidenced that one of the most common causes in the failure of software security is the lack of identification and specification of requirements for information security, it is an activity with an insufficient importance in the software ...
Adán Beltrán G., Cristhian Lombana C., Mario Calvo L., Sonia Ordoñez S., Yaneth Caviativa C., Jairo Garcés   +5 more
doaj   +1 more source

Monitoring-Oriented Programming: A Tool-Supported Methodology for Higher Quality Object-Oriented Software [PDF]

, 2004
This paper presents a tool-supported methodological paradigm for object-oriented software development, called monitoring-oriented programming and abbreviated MOP, in which runtime monitoring is a basic software design principle.
Chen, Feng, d'Amorim, Marcelo, Rosu, Grigore   +2 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

QUALITY IMPROVING GRAPH MODEL AND METHOD FOR Software requirements specification

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The graph model for software requirements specification is proposed. Besides, there are possible actions of improving the quality characteristics of software requirements described.
A. U. Chirkova, V. V. Bakhtizin
doaj  

A Document-Driven Method for Certifying Scientific Computing Software for Use in Nuclear Safety Analysis

Nuclear Engineering and Technology, 2016
This paper presents a documentation and development method to facilitate the certification of scientific computing software used in the safety analysis of nuclear facilities.
W. Spencer Smith, Nirmitha Koothoor
doaj   +1 more source

A reference measurement framework of software security product quality (SPQNFSR)

IET Information Security, 2021
Currently, the customer's demands have expressively amplified their expectations of getting software at a high‐quality level. However, the non‐functional requirements of the software products attention have been expanded in both the academic and the ...
Khalid T. Al‐Sarayreh, Mamdouh Alenezi, Mohammed Zarour, Kenza Meridji   +3 more
doaj   +1 more source

Requirements Variability Specification for Data Intensive Software [PDF]

International Journal of Software Engineering & Applications, 2019
Nowadays, the use of feature modeling technique, in software requirements specification, increased the variation support in Data Intensive Software Product Lines (DISPLs) requirements modeling. It is considered the easiest and the most efficient way to express commonalities and variability among different products requirements. Several recent works, in
Muslah, Eman, Ghoul, Said
openaire   +2 more sources

Requirements analysis of the VoD application using the tools in TRADE [PDF]

, 1996
This report contains a specification of requirements for a video-on-demand (VoD) application developed at Belgacom, used as a trial application in the 2RARE project. The specification contains three parts: an informal specification in natural language; a
Huyts, Sander, Wieringa, R.J.
core   +2 more sources