Results 221 to 230 of about 6,176,166 (267)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Exploring the physiological limits of aging: a case study of the male 50-km world record in the 80+ age category. [PDF]

Front Physiol
Pilotto AM, Higueras-Liébana E, Ansaldo M, Baltasar-Fernandez I, Neri M, Giusti L, Buendía-Romero Á, Valenzuela PL, Alcazar J, Lauretani F, Re R, Botter A, Franchi MV, Ara I, Porcelli S.   +14 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Prognostic value of baseline QFR in single-vessel intermediate coronary stenosis. [PDF]

Front Cardiovasc Med
Lu Y, AlQazzaz A, Bao JY, Mintz GS, Feng J, Zhang Y, Gao S, Song Q, Ning F, Huang X, Guo N.   +10 more
europepmc   +1 more source

The IBEX knowledge-base a community resource enabling adoption and development of immunofluorescence imaging methods. [PDF]

Elife
Yaniv Z, Anidi IU, Arakkal L, Arroyo-Mejías AJ, Beuschel RT, Börner K, Chu CJ, Clark BH, Clatworthy MR, Colautti J, Coscia F, Croteau J, Denha S, Dever R, Dutra WO, Fritzsche S, Fullam S, Gerner MY, Gola A, Gollob KJ, Hernandez JM, Hor JL, Ichise H, Jing Z, Jonigk D, Kandov E, Kastenmüller W, Koenig JFE, Kothurkar A, Kortekaas RK, Kreins AY, Lamborn IT, Lin Y, Luciano Pereira Morais K, Lunich A, Luz JCS, MacDonald RB, Makranz C, Maltez VI, McDonough JE, Moriarty RV, Ocampo-Godinez JM, Murakami Olyntho V, Oxenius A, Padhan K, Remmert K, Richoz N, Schrom EC, Shang W, Shi L, Shih RM, Speranza E, Stierli S, Teichmann SA, Verse TZ, Vierhout M, Wachter BT, Wade-Vallance AK, Williams M, Zangger N, Germain RN, Radtke AJ.   +61 more
europepmc   +1 more source

Mapping drug mechanisms with ProteomicsDB: unified omics and cell sensitivity data at scale. [PDF]

Nucleic Acids Res
Picciani M, Soleymaniniya A, Müller J, Sakhteman A, Tzanakis K, Bernett J, Kahl E, Hamood F, Kersting J, Pourjam M, Nagai LAE, List M, Kuster B, The M, Wilhelm M.   +14 more
europepmc   +1 more source

OncoDB 2.0: a comprehensive platform for integrated pan-cancer omics analysis. [PDF]

Nucleic Acids Res
Cho M, Tang G, Rogers CS, Dove M, Liu X, Li Y, Wang X.   +6 more
europepmc   +1 more source