Results 81 to 90 of about 6,176,166 (267)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Software Architecture Degradation in Open Source Software: A Systematic Literature Review
IEEE Access, 2020 Software architecture (SA) has a prominent role in all stages of system development. Given the persistent evolution of software systems over time, SA tends to be eroded or degraded. Such phenomenon is called architectural degradation.
Ahmed Baabad +3 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
SOFTWARE REVIEW,LIMDEP 7.0 [PDF]
فصلنامه پژوهشهای اقتصادی ایران, 2001 نرم افزارLimdep یک برنامه رایانه ای برای تخمین و تحلیل مدل های رگرسیونی و نیز مدل های دارای متغیرهای وابسته کیفی و یا محدود شده است. تاکنون برنامه ای که نسبت به این برنامه تنوع بیشتری از لحاظ چهارچوب های مدلبندی، ابزارها و مشخصات تحلیل داده های مقطعی ...
Saeed Moshiri, Morteza Naderi
doaj
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Software review: The JATSdecoder package-extract metadata, abstract and sectioned text from NISO-JATS coded XML documents; Insights to PubMed central's open access database. [PDF]
Scientometrics, 2021 Böschen I.
europepmc +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
The Dynamics of Creativity in Software Development
, 2013 Software is primarily developed for people by people and human factors must be studied in all software engineering phases. Creativity is the source to improvise solutions to problems for dominating complex systems such as software development.
Graziotin, Daniel
core +2 more sources