Results 121 to 130 of about 32,056,537 (304)

DBCD: Dual Branch Contrastive Diffusion Network for Unsupervised Building Extraction

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Generative artificial intelligence has reshaped perspective on data representation of remote sensing images (RSIs), offering powerful solutions for regions lacking annotated data.
Chengming Zhang, Shengkai Gao, Xin Lyu, Yiwei Fang, Jue Zhang, Fan Liu, Hongmin Gao, Xin Li   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Does software piracy always represent consumer misbehaviour? [PDF]

, 2011
This study aims to explore whether or not software piracy is perceived as consumer misbehaviour in Libya. Both qualitative and quantitative methods have been used; data were collected by interviewing 10 marketers and through a questionnaire surveying 219
Whysall, P, Abdelhadi, A., Abdelhadi, A, Foster, C, Whysall, P., Foster, Carley   +5 more
core  

PAFNet: A Parallel Attention Fusion Network for Water Body Extraction of Remote Sensing Images

Remote Sensing
Water body extraction plays a crucial role in remote sensing, supporting applications such as environmental monitoring and disaster prevention. Although Deep Convolutional Neural Networks (DCNNs) have achieved remarkable progress, their hierarchical ...
Shaochuan Chen, Chenlong Ding, Mutian Li, Xin Lyu, Xin Li, Zhennan Xu, Yiwei Fang, Heng Li   +7 more
doaj   +1 more source

Where's the science in software engineering?

Ubiquity, 2014
This article is a personal account of the methodological evolution of software engineering research from the 1970s to the present.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Computational Science Software and Articles

This site introduces computational science with a brief overview which distinguishes computational science ("use primarily of computation, rather than of theorizing or experimentation, to attain scientific knowledge") from computer science ...

core  

Study on neural network proportional-integration-differential (PID) control strategy of the molten metal pool level in the twin roll casting process

Metalurgija, 2020
In the twin-roll casting process, how to accurately control the molten metal pool level is a key problem to produce high quality strip. In this paper, the mathematical model about the pool level control is set up based on the process characteristics ...
S. Y. Guan, W. Y. Zhang, X. Xia, Y. F. Jiang   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source