Results 101 to 110 of about 32,056,537 (304)
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Software science analysis of PROLOG
, 1994 The theory of software science attempts formularization of software characteristics. It was developed by the late M. H. Halstead of Purdue University during the early 1970's.
Ahmad,Aftab
core
CytoAnalyst web platform facilitates comprehensive single cell RNA sequencing analysis
Scientific ReportsSingle-cell technologies have revolutionized our ability to study cellular heterogeneity and dynamics at unprecedented resolutions. In this fast-growing field, it becomes increasingly challenging to navigate the vast number of tools and steps for ...
Phi Bya +4 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Carrying Ideas from Knowledge-Based Configuration to Software Product Lines [PDF]
, 2016 Software variability modelling (SVM) has become a central concern in software product lines -- especially configurable software product lines (CSPL) require rigorous SVM.
Varvana Myllärniemi +7 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Software Heritage, Key Infrastructure For Open Science And Software Science
Software Heritage collects publicly available source code from numerous software projects and tracks their ongoing development. Outline1 Introduction2 Software and Source Code3 An emerging policy framework for Open Science4 Software Heritage for Open Science and Reproducibility5 Software Heritage for Research on Software6 Efficient traversal of the ...
Di Cosmo, Roberto, Software Heritage
openaire +3 more sources
Open Software for Open Science
, 2015 This presentation to the Young Alliance Against Cancer workshop in Copenhagen on 23rd May 2015 describes the benefits of open source software and philosophies to scientific research.
openaire +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source