Results 91 to 100 of about 32,056,537 (304)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Multi-Stage Frequency Attention Network for Progressive Optical Remote Sensing Cloud Removal

Remote Sensing
Cloud contamination significantly impairs optical remote sensing images (RSIs), reducing their utility for Earth observation. The traditional cloud removal techniques, often reliant on deep learning, generally aim for holistic image reconstruction, which
Caifeng Wu, Feng Xu, Xin Li, Xinyuan Wang, Zhennan Xu, Yiwei Fang, Xin Lyu   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Developing Scientific Computing Software: Current Processes and Future Directions [PDF]

, 2008
Considerable emphasis in scientific computing (SC) software development has been placed on the software qualities of performance and correctness.
Tang, Jin
core  

Generative AI in Intrusion Detection Systems for Internet of Things: A Systematic Literature Review

IEEE Open Journal of the Communications Society
The ubiquitous data streaming through the Internet of Things (IoT) creates security risks. Intrusion detection systems (IDS) based on machine learning can support user security.
Zhe Deng, Ants Torim, Sadok Ben Yahia, Hayretdin Bahsi   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

An Investigation into Software Estimation Methods [PDF]

There are currently no fully validated estimation approaches that can accurately predict the effort needed for developing a software system (Kitchenham, et al, 1995).
Hamdan, Khaled
core   +5 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Efficient Adaptation of Vision Foundation Model for High-Resolution Remote Sensing Image Segmentation via Spatial-Frequency Modeling and Sparse Refinement

Remote Sensing
High-resolution remote-sensing semantic segmentation requires models to simultaneously capture global scene semantics and preserve fine-grained local structures.
Chenlong Ding, Chengyi Shi, Daofang Liu, Zhihao Shi, Xin Lyu, Zhenyu Fang, Xue Liu, Lingqiang Meng, Yiwei Fang, Chengming Zhang, Xin Li   +10 more
doaj   +1 more source