Results 91 to 100 of about 3,923,394 (245)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

CytoAnalyst web platform facilitates comprehensive single cell RNA sequencing analysis

Scientific Reports
Single-cell technologies have revolutionized our ability to study cellular heterogeneity and dynamics at unprecedented resolutions. In this fast-growing field, it becomes increasingly challenging to navigate the vast number of tools and steps for ...
Phi Bya, Duy Tran, Khoi Nguyen, Sorin Draghici, Tin Nguyen   +4 more
doaj   +1 more source

The Public Archives at the NASA Michelson Science Center [PDF]

, 2007
This presentation describes the scientific data sets and user services accessible through the public archive at the Michelson Science Center (MSC). The MSC is charged by NASA with providing long-term data archiving capabilities for the Navigator Program,
Berriman, G. Bruce
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

DBCD: Dual Branch Contrastive Diffusion Network for Unsupervised Building Extraction

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Generative artificial intelligence has reshaped perspective on data representation of remote sensing images (RSIs), offering powerful solutions for regions lacking annotated data.
Chengming Zhang, Shengkai Gao, Xin Lyu, Yiwei Fang, Jue Zhang, Fan Liu, Hongmin Gao, Xin Li   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Efficient Adaptation of Vision Foundation Model for High-Resolution Remote Sensing Image Segmentation via Spatial-Frequency Modeling and Sparse Refinement

Remote Sensing
High-resolution remote-sensing semantic segmentation requires models to simultaneously capture global scene semantics and preserve fine-grained local structures.
Chenlong Ding, Chengyi Shi, Daofang Liu, Zhihao Shi, Xin Lyu, Zhenyu Fang, Xue Liu, Lingqiang Meng, Yiwei Fang, Chengming Zhang, Xin Li   +10 more
doaj   +1 more source

Hands-On Physical Science for In-Service Teachers [PDF]

, 2004
The initiation of the Virginia Commonwealth University B.S. in Science program was reported in this journal Fall 1999 as a program designed to meet the academic content major of a teacher preparation program for elementary and middle school mathematics ...
Baski, A., Lewis, D., McDonnough, J., McKelvey, S.   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source