Results 71 to 80 of about 32,056,537 (304)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Checklist for a Software Management Plan

, 2016
It is easy to concentrate on short-term issues when developing research software. Getting publications, collaboration with others and the demands of a daily research routine can all conspire to prevent proper planning for the development of research ...
The Software Sustainability Institute
core   +1 more source

Software energy profiling: comparing releases of a software product [PDF]

, 2016
In the quest for energy efficiency of Information and Communication Technology, so far research has mostly focused on the role of hardware. However, as hardware technology becomes more sophisticated, the role of software becomes crucial.
Lago, Patricia, Jan Martijn van der Werf, Brinkkemper, Sjaak, Patricia Lago, Lago, P.; id_orcid, Jagroep, Erik, Rob van Vliet, Procaccianti, G.; id_orcid, Blom, Leen, Procaccianti, Guiseppe, Sub Algemeen Software Systems, Sub Software Production, Brinkkemper, S., Erik A. Jagroep, Leen Blom, Software Production, Blom, L., Giuseppe Procaccianti, van Vliet, Rob, Sjaak Brinkkemper, Jagroep, E.A., van der Werf, J.M.E.M.   +21 more
core   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Supporting adaptation of decentralized software based on application scenarios

, 2013
Software systems formed by autonomous software entities are greatly different from traditional software systems and it challenges researchers to find effective methods of supporting the adaptation of software systems.
Sun, Yanchun, Jiao, Wenpin
core   +1 more source

Containers in Software Development : A Systematic Mapping Study [PDF]

, 2019
Over the past decade, continuous software development has become a common place in the field of software engineering. Containers like Docker are a lightweight solution that developers can use to deploy and manage applications.
Mikkonen, Tommi, Abrahamsson, Pekka, Koskinen, Mikael, Tommi Mikkonen, Pekka Abrahamsson, Mikael Koskinen   +5 more
core   +1 more source

A Novel Hybrid Multi-Objective Particle Swarm Optimization Algorithm With an Adaptive Resource Allocation Strategy

IEEE Access, 2019
Recently, there are a number of particle swarm optimization algorithms (PSOs) proposed for tackling multi-objective optimization problems (MOPs). Most of multi-objective PSOs (MOPSOs) were designed to speed up their convergence, which have been validated
Lingjie Li, Shuo Chen, Zhe Gong, Qiuzhen Lin, Zhong Ming   +4 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Evolutionary success of open source software: An investigation into exogenous drivers [PDF]

, 2007
Copyright @ 2007 EASSTThe “success” of a Free/Libre/Open Source Software (FLOSS) project has often been evaluated through the number of commits made to its configuration management system, number of developers and number of users.
Rank, S, Rank, Stephen, Boldyreff, Cornelia, Capiluppi, Andrea, Capiluppi, Andrea; id_orcid, Beecher, K, Beecher, Karl, Capiluppi, A, Boldyreff, C   +8 more
core   +2 more sources