Results 51 to 60 of about 117,876 (267)

Green DevOps: A Strategic Framework for Sustainable Software Development

Computer Sciences & Mathematics Forum
In the era of digital transformation, the environmental impact of software development has become a pressing concern, necessitating the integration of sustainability into software development processes.
Mohamed Toufik Ailane, Carolin Rubner, Andreas Rausch   +2 more
doaj   +1 more source

Sustainability-centric integration software requirements validation [PDF]

MATEC Web of Conferences
Software Development Life Cycle (SDLC) is enriched with different phases. Requirement Analysis is predominant in designing and developing the software application with proper functionality and to produce expected outcome.
Kandukuri Prabhakar, Syma Kumar Dasari N.V., Ramesh G., Kativarapu Prathima   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Software sustainability of global impact models [PDF]

Geoscientific Model Development
Research software for simulating Earth processes enables the estimation of past, current, and future world states and guides policy. However, this modelling software is often developed by scientists with limited training, time, and funding, leading to ...
E. Nyenah, P. Döll, P. Döll, D. S. Katz, R. Reinecke   +4 more
doaj   +1 more source

Software Sustainability

, 2016
The Dutch Digital Heritage Network (NDE) and the Netherlands Coalition for Digital Preservation (NCDD) consist of partners in a number of sectors: science, archiving, libraries, art and broadcasting. In all these sectors the NDE and NCDD members are faced with many different aspects of software obsolescence, in agreement with the rapidly growing ...
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Sustained Software for Cyberinfrastructure [PDF]

Proceedings of the 1st Workshop on The Science of Cyberinfrastructure: Research, Experience, Applications and Models, 2015
Reliable software that provides needed functionality is clearly essential for an effective distributed cyberinfrastructure (CI) that supports comprehensive, balanced, and flexible distributed CI. Effective distributed cyberinfrastructure, in turn, supports science and engineering applications.
Craig A. Stewart, William K. Barnett, Eric A. Wernert, Julie A. Wernert, Von Welch, Richard Knepper   +5 more
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source