Results 71 to 80 of about 1,434,557 (269)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Research on Noise Management Technology for Fully Homomorphic Encryption

IEEE Access
Fully homomorphic encryption (FHE) has gradually become an important tool for solving data security and privacy protection issues, because it supports arbitrary computation of encrypted data without the need for prior decryption.
Lifang Bai, Lijuan Bai, Yongjun Li, Zecun Li   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Software testing in microbial bioinformatics: a call to action. [PDF]

Microb Genom, 2022
van der Putten BCL, Mendes CI, Talbot BM, de Korne-Elenbaas J, Mamede R, Vila-Cerqueira P, Coelho LP, Gulvik CA, Katz LS, The Asm Ngs Hackathon Participants.   +9 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effective Seed Scheduling for Directed Fuzzing with Function Call Sequence Complexity Estimation

Applied Sciences
Directed grey-box fuzzers focus on testing specific target code. They have been utilized in various security applications, such as reproducing known crashes and identifying vulnerabilities resulting from incomplete patches.
Xi Peng, Peng Jia, Ximing Fan, Cheng Huang, Jiayong Liu   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

AMRerank: A Framework for Library Migration Recommendations Using Multi-Agent Analysis and Data-Driven Reranking

IET Software
Open-source libraries are indispensable for modern software development but can create substantial maintenance burdens when they become deprecated or unmaintained.
Jie Luo, Zijie Huang, Jianhua Gao
doaj   +1 more source

Sign Language Recognition Based on CNN-BiLSTM Using RF Signals

IEEE Access
As the number of individuals with speech and hearing impairments continues to grow, the demand for sign language recognition systems is increasing. Furthermore, most radio frequency-based gesture recognition systems have primarily focused on simple ...
Yajun Zhang, Yuankang Wang, Feng Li, Weiqian Yu, Congcong Wang, Ying Jiang   +5 more
doaj   +1 more source

Accelerating covering array generation by combinatorial join for industry scale software testing. [PDF]

PeerJ Comput Sci, 2022
Ukai H, Qu X, Washizaki H, Fukazawa Y.
europepmc   +1 more source