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Global and Local Implications of Computational Artifacts

Philosophia Scientiæ
This article investigates the undone science of software scalability. Software engineering literature focuses on the multiple ways that software can scale up, but too rarely on the possibilities, or necessities, of making it scale down.
Pierre Depaz
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Pattern-Based Coarse-Grained Component Modelling for Enterprise Application Software Developing

MATEC Web of Conferences, 2016
To improve the efficiency of ESA (Enterprise Application Software) development, component-based software development is a good solution. However, though those general software components, like JavaBean, COM/COM+ (Component Object Model), are maturely ...
Li Hai Bo, Liang Meng Xia, Gao Ya Feng
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Sonocubic fine: new three-dimensional ultrasound software to the screening of congenital heart diseases

Brazilian Journal of Cardiovascular Surgery, 2014
Congenital heart disease is the most common fetal congenital malformations; however, the prenatal rate detection still is low. The two-dimensional echocardiography is the "gold standard" exam to screening and diagnosis of congenital heart disease during ...
Edward Araujo Júnior, Luciane Alves da Rocha, Luciano Marcondes Machado Nardozza   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Are cognitive functions in post-menopausal women related with the contents of macro- and micro-components in the diet?

Annals of Agricultural and Environmental Medicine, 2015
Introduction The objective of the study was an evaluation of the relationship between the level of cognitive functions and contents of micro- and macro-components in the diet of postmenopausal women. A group of 402 women was recruited to the study.
Iwona Bojar, Anna Wierzbińska-Stępniak, Mariusz Witczak, Dorota Raczkiewicz, Alfred Owoc   +4 more
doaj   +3 more sources

Is it not too redundant? When signaling overlap reduces extraneous load and enhances retention in a software video tutorial

Frontiers in Psychology
The redundancy effect in Cognitive Load Theory posits that presenting overlapping information across multiple channels (e.g., duplicate auditory and visual content) can impede learning by increasing extraneous cognitive load and hindering mental model ...
Juliette C. Désiron, Juliette C. Désiron, Tino Endres, Tino Endres, Tino Endres, Sascha Schneider   +5 more
doaj   +1 more source