Results 81 to 90 of about 6,706,538 (285)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Statistical Software for State Space Methods

Journal of Statistical Software, 2011
In this paper we review the state space approach to time series analysis and establish the notation that is adopted in this special volume of the Journal of Statistical Software.
Jacques J. F. Commandeur, Siem Jan Koopman, Marius Ooms   +2 more
doaj  

Open-source GIS software and tools: a systematic review

Big Earth Data
Geographic science explores the interactions among natural and human elements and their spatiotemporal patterns. Open-source geographic information systems (GIS), with their freedom, openness, and sharing, are gradually being used in geographical ...
Qing Geng, Xiaochuang Yao, Jialin Sun, Shijin Jia, Fan Xu, Lianchong Zhang, Bingbo Gao, Shaohua Wang, Quanlong Feng, Jianyu Yang, Guoqing Li   +10 more
doaj   +1 more source

Prediction of Mutations to Control Pathways Enabling Tumor Cell Invasion with the CoLoMoTo Interactive Notebook (Tutorial)

Frontiers in Physiology, 2018
Boolean and multi-valued logical formalisms are increasingly used to model complex cellular networks. To ease the development and analysis of logical models, a series of software tools have been proposed, often with specific assets.
Nicolas Levy, Nicolas Levy, Aurélien Naldi, Céline Hernandez, Gautier Stoll, Gautier Stoll, Gautier Stoll, Gautier Stoll, Gautier Stoll, Denis Thieffry, Andrei Zinovyev, Andrei Zinovyev, Andrei Zinovyev, Andrei Zinovyev, Laurence Calzone, Laurence Calzone, Laurence Calzone, Loïc Paulevé   +17 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Mapping the Use of Bibliometric Software and Methodological Transparency in Literature Review Studies: A Comparative Analysis of China-Affiliated and Non-China-Affiliated Research Communities (2015–2024)

Publications
The growing use of bibliometric methods in literature reviews has intensified concerns about methodological transparency and consistency. This study compares English-language reviews authored by China-affiliated and non-China-affiliated researchers ...
Altyeb Ali Abaker Omer, Yajie Dong
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ESM-Tools 5.1.6

, 2021
To assist researchers and modellers by reducing avoidable complexity, we developed the ESM-Tools software, which provides a standard way for downloading, configuring, compiling, running and monitoring different models on a variety of High Performance ...
Deniz Ural, Jan Streffing, Cristini, Luisa, Dirk Barbi, Wieters, Nadine, Ural, Deniz, Kjellsson, Joakim, Gierz, Paul, Joakim Kjellsson, Barbi, Dirk, Sebastian Wahl, Paul Gierz, Miguel Andrés-Martinez, Luisa Cristini, Nadine Wieters, Wahl, Sebastian, Andrés-Martínez, Miguel   +16 more
core   +1 more source

ALGORITHMIC APPROACH TO OPTIMAL RESOURCE CONTROL IN AN OPEN ECONOMY MODEL

Journal of Problems in Computer Science and Information Technologies
The dynamic development of the global economy and the impact of external factors create challenges for ensuring sustainable growth, making effective resource management an urgent task.
Kamshat Tussupova, Gulbanu Mirzakhmedova, Assem Shormakova   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source