Results 61 to 70 of about 1,093,401 (218)

Prediction of Mutations to Control Pathways Enabling Tumor Cell Invasion with the CoLoMoTo Interactive Notebook (Tutorial)

Frontiers in Physiology, 2018
Boolean and multi-valued logical formalisms are increasingly used to model complex cellular networks. To ease the development and analysis of logical models, a series of software tools have been proposed, often with specific assets.
Nicolas Levy, Nicolas Levy, Aurélien Naldi, Céline Hernandez, Gautier Stoll, Gautier Stoll, Gautier Stoll, Gautier Stoll, Gautier Stoll, Denis Thieffry, Andrei Zinovyev, Andrei Zinovyev, Andrei Zinovyev, Andrei Zinovyev, Laurence Calzone, Laurence Calzone, Laurence Calzone, Loïc Paulevé   +17 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Statistical Software for State Space Methods

Journal of Statistical Software, 2011
In this paper we review the state space approach to time series analysis and establish the notation that is adopted in this special volume of the Journal of Statistical Software.
Jacques J. F. Commandeur, Siem Jan Koopman, Marius Ooms   +2 more
doaj  

Mapping the Use of Bibliometric Software and Methodological Transparency in Literature Review Studies: A Comparative Analysis of China-Affiliated and Non-China-Affiliated Research Communities (2015–2024)

Publications
The growing use of bibliometric methods in literature reviews has intensified concerns about methodological transparency and consistency. This study compares English-language reviews authored by China-affiliated and non-China-affiliated researchers ...
Altyeb Ali Abaker Omer, Yajie Dong
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Open-source GIS software and tools: a systematic review

Big Earth Data
Geographic science explores the interactions among natural and human elements and their spatiotemporal patterns. Open-source geographic information systems (GIS), with their freedom, openness, and sharing, are gradually being used in geographical ...
Qing Geng, Xiaochuang Yao, Jialin Sun, Shijin Jia, Fan Xu, Lianchong Zhang, Bingbo Gao, Shaohua Wang, Quanlong Feng, Jianyu Yang, Guoqing Li   +10 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

ALGORITHMIC APPROACH TO OPTIMAL RESOURCE CONTROL IN AN OPEN ECONOMY MODEL

Journal of Problems in Computer Science and Information Technologies
The dynamic development of the global economy and the impact of external factors create challenges for ensuring sustainable growth, making effective resource management an urgent task.
Kamshat Tussupova, Gulbanu Mirzakhmedova, Assem Shormakova   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source