Results 41 to 50 of about 6,706,538 (285)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
New concepts in the design of an IoT electric torque wrench‐based on a smart meter chip
Engineering ReportsElectric torque wrenches play a critical role in the assembly process of high‐strength bolts. This study focuses on three assembly processes for high‐strength bolts and introduces two statistical analysis methods to evaluate the quality of bolt assembly.
Zhaohui Meng +3 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Contemporary concept of management of lans of supply with information and communication technology [PDF]
Ekonomski Signali, 2019 In the paper, after the introductory remarks and explanations of what is the supply chain, the supply chain management, it is considered and why the supply chain differs from the concept of logistics management.
Mitrović Vladimir, Mitrović Ivana
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Intuitive Ontology-Based SPARQL Queries for RDF Data Exploration
IEEE Access, 2019 This paper introduces a strategy for both the retrieval and analysis of linked open data (LOD) based on the use of visual tools. Retrieving and understanding data from triplestores (such as SPARQL) requires technical knowledge and proves to be ...
Alejandro Rodriguez Diaz +5 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Accuracy Test of Software Architecture Compliance Checking Tools – Test Instruction [PDF]
, 2015 Software Architecture Compliance Checking (SACC) is an approach to verify conformance of implemented program code to high-level models of architectural design.
Brinkkemper., Sjaak +4 more
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Characterization and Classification of Collaborative Tools [PDF]
, 2010 Traditionally, collaboration has been a means for organizations to do their work. However, the context in which they do this work is changing, especially in regards to where the work is done, how the work is organized, who does the work, and with this ...
Rafael Fernandez +5 more
core +1 more source
Perspectives in Clinical ResearchPrevious articles in this series have looked at various aspects of planning, designing, conducting and interpreting biomedical research. In this article, we offer an overview of some tools and resources available to health and biomedical researchers, to ...
Vishal Deo, Priya Ranganathan
doaj +1 more source